The treatment of dyslipidemia depends on the type and severity of the condition and the presence of other risk factors, such as diabetes, hypertension, obesity, or smoking. The main goals of treatment are to lower LDL cholesterol, raise HDL cholesterol, and reduce triglycerides. Preventing dyslipid...
Objective: Statin treatment compliance and achieving target levels differ between populations. This study aimed to determine the status of achieving the lipid targets and evaluate patients' compliance to statin treatment in type 2 diabetic patients with dyslipidemia. Method: This cross-sectional study ...
Table 1 Low-density Lipoprotein Cholesterol (LDL-C) and Non-HDL-C Goals for Patients in Different CVD Risk Categories from the Adult Treatment Panel III of the National Cholesterol Education Program [12,30] Full size table Characteristics and mechanisms of lipoprotein abnormalities in type 2 diabet...
LDL LDL = Total chol – HDL – (Triglyerides / 5) = 220 – 20 – (150/5) = 170 mg/dL Clinical approach 1) 2) 3) 4) Identify CAD or equivalents Identify other CV risk factors Assess CAD risk - Framingham Determine goal LDL level, treatment options Clinical approach – Step 1 ?
For the past 2 decades, guidelines for reducing atherosclerosis have based risk and set treatment goals on LDL-cholesterol (LDL-C). However, with the rapidly increasing emergence of insulin resistance, metabolic syndrome, and type 2 diabetes, elevated triglyceride (TG) and reduced HDL-cholesterol ...
Treatment The treatment depends on the symptoms, age, and overall health of the patient. Your healthcare provider may prescribe you the following medications: probucol (an anti-hyperlipidemic drug); nicotinic acid (a form of vitamin B3);
• Treatment • Special scenarios – hypertriglycerides and low HDL • Other real world concerns Tr eat ment opt i ons • Lifestyle modifications • Medications –HMG Co-A inhibitors (“statins”) –Other drugs Li f est yl e modi f i c at i ons ...
Although hypertriglyceridemia plays a central role in the pathophysiology of diabetic dyslipidemia, lowering LDL remains the primary treatment target. The first step in determining treatment goals for diabetic patients is a comprehensive assessment of their cardiovascular risk. The American Diabetes Association...
genes with www.intechopen.com 48 Dyslipidemia - From Prevention to Treatment functionally important variations; genes that have an important hierarchical role in biological cascades; polymorphisms that are highly prevalent in the population (usually >10% for public health relevance); and/or genes with...
Knowledge of cholesterol metabolism is essential for understanding dyslipidemia and the drugs used in its treatment. Although statins remain the first line of pharmacotherapy, novel lipid-lowering therapies are currently available, such as PCSK9 inhibitors; gene therapy, including small interfering RNAs (...