Moreover, the Seed Connector algorithm (SCA) algorithm suggested a putative role of the neuropilin-1 (NRP1) protein as drug target, whereas a regression network analysis reported that niacin may provide benefits in mixed dyslipidemias. Dyslipidemias are highly heterogeneous at the clinical level; ...
Notably, the 2019 ESC/EAS guidelines outline a treatment algorithm that involves a stepwise escalation of drug therapy if LDL-C goals are not attained in high and very high-risk patients. According to this algorithm, statins, such as simvastatin, atorvastatin or rosuvastatin are the first step ...
Table 8. Proposed Treatment Algorithm for Lipid Management in Patients With CKD (Stage 3 to 5) Lipid DisorderTherapeutic Option (See Table 7 for Dose Adjustments) Moderate to severe CKD, stages 3 to 4 (GFR 15–59 ml/min/1.73 m2) Elevated LDL-C Mixed dyslipidemia⁎ (not at non-HDL...
Dyslipidemia is a common disorder of abnormal metabolism or levels of one or more of various triglyceride or cholesterol molecules. Based on the most recent guidelines established by the National Cholesterol Education Program (NCEP) Adult Treatment Panel III, approximately 23% of the United States pop...
algorithm of treatment guidelines for ASCVDa high-intensity statin daily dose lowers LDL-C on average, by approximately ≥50% a moderate-intensity statin daily dose lowers LDL-C on average, by approximately 30-50% a low-intensity statin daily dose lowers LDL-C on average, by approximately ≤...
Development and validation of an algorithm to establish a total antioxidant capacity database of the US diet. Int J Food Sci Nutr. 2010;61: 600–23. 22. Serafini M, Bellocco R, Wolk A, Ekström AM. Total antioxidant potential of fruit and vegetables and risk of gastric cancer. ...
The primary objective of the CanACTFAST (Canadians Achieve Cholesterol Targets Fast with Atorvastatin Stratified Titration) trial was to determine whether a preselected algorithm of atorvastatin dosage based on the patients' cardiovascular risk category and level of LDL-C enables patients to achieve ...
Performance of the QRISK cardiovascular risk prediction algorithm in an independent UK sample of patients from general practice: a validation study. Heart. 2008;94(1):34-39. doi:10.1136/hrt.2007.134890 PubMedGoogle ScholarCrossref 70. Woodward M, Brindle P, Tunstall-Pedoe H...
Considering the relevance and usefulness of non-HDL-C, recent ESC guidelines for CVD prevention (2020) also use non-HDL-C as input in the Systematic Coronary Risk Estimation 2 (SCORE-2) algorithm for assessing disease risk [38]. The Residual Risk Reduction Initiative (R3i), a globally ...
Usefulness of treatment goals Most RCTs of lipid-lowering drug therapies have tested drug treatment against a placebo control, or a more intensive with a less-intensive treatment regimen. The strategy of treating patients to a specific level of LDL-C or non-HDL-C has not been tested in any...