Pure autonomic failure is arare degenerative disorderthat causes orthostatic hypotension, sexual dysfunction, a decreased ability to sweat, elevated blood pressure when lying down, and changes in gastrointestinal and urinary habits.
significant neuronal disruption also occurring in the coeliacomesenteric ganglia.Ileal neuronal damage and loss are not invariably worse than that in the jejunum, and the possible reasons for this, together with the relationship between neuronal damage and possible causes of dysautonomia, are discussed...
Familial dysautonomia (FD) is a rare genetic neurologic disorder caused by impaired neuronal development and progressive degeneration of both the peripheral and central nervous systems. FD is monogenic, with >99.4% of patients sharing an identical point mutation in the elongator acetyltransferase complex...
4b), suggesting that FD iPSCs may differentiate into other cell types, likely non-neural ectoderm, rather than die. In addition, using RT-qPCR analysis, we found significant expression of SIX1+/EYA1+ placode contaminants (Supplementary Fig. 4c). However, we previously showed that non-NCCs ...
Deletion of exon 20 of the familial dysautonomia gene Ikbkap in mice causes developmental delay, cardiovascular defects, and early embryonic lethality PLoS One, 6 (2011), p. e27015 CrossrefView in ScopusGoogle Scholar 36 P. Dietrich, S. Alli, R. Shanmugasundaram, I. Dragatsis IKAP expressio...
Team PainAssist - January 29, 2019 There are around 30,000 types of spiders and among them, the black widow spider is the most popular and the most dreaded one. There... View Article Load moreHot Topics Causes of Nociceptive Somatic Pain: Traumatic Injuries, Blunt Trauma, Penetrating Inj...
Intestinal inflammation during chronic experimental TBI causes a sustained systemic immune response and altered autonomic balance that are associated with microglial activation, increased neurodegeneration, and persistent neurological deficits. Background
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