Fundamentals of the Dynorphins/Kappa Opioid Receptor System: From Distribution to Signaling and FunctionIn vivo pharmacologyKOR/dynorphinsNeuroanatomyReviewSignalingThis chapter provides a general introduction to the dynorphins (DYNs)/kappa opioid receptor (KOR) system, including DYN peptides, neuroanatomy ...
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Because the scientists have demonstrated a possible neurobiological function for this particular genetic variant, it is referred to as a "functional variation." "Knowing how this genetic variation could potentially modulate the effects of cocaine lends weight to our results," says Chen. "But, on th...
Molecular aspects of neuropeptide regulation and function in the corpus striatum and nucleus accumbens. In the corpus striatum and nucleus accumbens, neuropeptides participate along with conventional neurotransmitters such as dopamine, gamma-aminobutyric acid... JA Angulo,BS Mcewen - 《Brain Research Brain...
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We present an overview of studies outlining the scope of cardiovascular and cerebrovascular processes that are affected by opioids, including heart function, ischemia, reperfusion, and blood flow. Specific emphasis is placed on the importance of dynorphin molecules in cerebrovascular and cardiovascular ...
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The results indicate that endogenous dynorphins function in this hippocampal circuit as retrograde, inhibitory neurotransmitters.doi:10.1038/363451a0Wagner, John J.Terman, Gregory W.Chavkin, CharlesNIH Public AccessNatureWagner, J. J., Terman, G. W., & Chavkin, C. (1993). Endogenous dynor- ph...
We determined the effects on nociceptive threshold and motor function of dynorphin-gene products, dynorphin A-(1–32) (DYN A-(1–32), DYN A-(1–8), DYN B and DYN B-29 and the non-opioid peptides somatostatin, neurotensin and salmon calcitonin (s-CT) after intrathecal administration in...
A cardiovascular modulatory function for Dyn A and related peptides was first suggested by the finding of Dyn A and K opioid receptors in brain nuclei and peripheral organs that are involved in the regulation of cardiovascular functions. However, measurement of the cardiovascular effects of Dyn A ...