Namely, this system modulates neural circuits that primarily regulate reward seeking, motivation processing, stress responsivity, and pain sensitivity, thus affecting the development of substance and alcohol use disorder (AUD). The effects of this system are often bidirectional and depend on projection ...
Twitter Google Share on Facebook dynorphin Medical Wikipedia (daɪˈnɔːfɪn)med n 1.(Medicine) a.an opioid peptide produced in the brain, used as a form of pain relief and in the treatment of cocaine addiction b.(as modifier):dynorphin blockers. ...
3.20.7.3.4Dynorphin and alcohol Many studies have identified an important role for dynorphin and KOR in alcohol use and dependence-associated withdrawal. Genetic polymorphisms in bothPdynandOprk1are associated with alcohol dependence (Xuei et al., 2006). Consistent with this observation, increased me...
Pattern of use and subjective effects of Salvia divinorum among recreational users. Drug Alcohol Depend 2006; 85: 157–62. PubMed Google Scholar Gillett K, Harshberger E, Valdez GR . Protracted withdrawal from ethanol and enhanced responsiveness stress: regulation via the dynorphin/kappa opioid ...
Epigenetic mechanisms of alcoholism and stress-related disorders factor (CRF), neuropeptide Y (NPY) and opioid peptides (i.e., nociceptin and dynorphin) are involved in the interaction of stress and alcohol. In... M Palmisano,SC Pandey - 《Alcohol》 被引量: 12发表: 2017年 Epigenetic Dysreg...
Ji D, Gilpin NW, Richardson HN, Rivier CL, Koob GF (2008) Effects of naltrexone, duloxetine, and a corticotropin-releasing factor type 1 receptor antagonist on binge-like alcohol drinking in rats. Behav Pharmacol 19:1–12 Article PubMed Google Scholar Jones DN, Holtzman SG (1992) Long te...
This work was supported by the National Institute on Drug Abuse and National Institute on Alcohol Abuse and Alcoholism (grant nos. DA033344, AA024146, AA006420, and AA022249 to RM-F and AA020608, AA006420, AA026081, and DA043799 to OG). REFERENCES Ammoun S, Holmqvist T, Shariat...
Individual differences within the 3′ untranslated region (3′UTR) of the PDYN gene have been shown to be associated with the abuse of various drugs, specifically cocaine, alcohol, and heroin (Clarke et al, 2009; Yuferov et al, 2009; Taqi et al, 2011). However, no study has yet ...
Abrupt withdrawal from chronic alcohol exposure can produce convulsions that are likely due to ethanol (EtOH) neuroadaptations. While significant efforts h... AS Beadles-Bohling,KM Wiren - 《Brain Research》 被引量: 65发表: 2005年 Safety, tolerability, and pharmacokinetic evaluation of single- and...
Dynorphins are critically involved in the development, maintenance and relapse of alcoholism. Alcohol-induced changes in the prodynorphin gene expression m... D'Addario, ClaudioShchetynsky, KlementyPucci, MariangelaCifani, CarloGunnar, AgnetaVukojevic, VladanaPadyukov, LeonidTerenius, Lars - Progres...