The mammalian dynein–dynactin complex is a strong opponent to kinesin in a tug-of-war competition. Nat. Cell Biol. 18, 1018–1024 (2016). Article PubMed PubMed Central CAS Google Scholar Zhang, K. et al. Cryo-EM reveals how human cytoplasmic dynein is auto-inhibited and activated. ...
Kinesin-14 HSET and KlpA are non-processive microtubule motors with load-dependent power strokes Xinglei Liu Lu Rao Arne Gennerich Nature Communications (2024) Effect of cytoskeletal geometry and motor protein arrangement on force generation and transport by motor proteins Aranyak Mitra Aurosikha ...
Mitosis only occurs when the nucleus reaches the VS. Two microtubule-associated motor proteins are required to drive nuclear movement: the unconventional kinesin, Kif1a, during G1-specific basal migration and cytoplasmic dynein during G2-specific apical migration. The strict coordination of motor ...
However, purified optic lobe dynein, like purified kinesin, does not by itself promote the movement of purified organelles along microtubles, suggesting that additional axoplasmic factors are necessary for retrograde as well as anterograde transport....
The structure of the complex can be divided into two distinct domains: the Arp1 rod and the projecting arm [21,22]. The projecting arm (consisting of the so-called sidearm and shoulder complex) links dynactin to cytoplasmic dynein, kinesin motors, and microtubules. It is composed of two dyn...
The structure of the complex can be divided into two distinct domains: the Arp1 rod and the projecting arm [21,22]. The projecting arm (consisting of the so-called sidearm and shoulder complex) links dynactin to cytoplasmic dynein, kinesin motors, and microtubules. It is composed of two dyn...
The small GTPase ARL8 associates with endolysosomes, leading to the recruitment of several effectors that couple endolysosomes to kinesins for anterograde transport along microtubules, and to tethering factors for eventual fusion with other organelles. Herein we report the identification of the RUN- and...
Mitochondria are transported along microtubules by opposing kinesin and dynein motors. Kinesin-1 and dynein-dynactin are linked to mitochondria by TRAK proteins, but it is unclear how TRAKs coordinate these motors. We used single-molecule imaging of cell
kinesinsKif11Kif18aKif25proximity ligation assayknocksidewaysHuman papillomaviruses (HPVs) travel from the trans-Golgi network (TGN) to the condensed (mitotic) chromosomes during mitosis. Partially uncoated HPV capsids utilize a unique vesicular structure for trafficking and nuclear import, which is ...
Mitosis only occurs when the nucleus reaches the VS. Two microtubule-associated motor proteins are required to drive nuclear movement: the unconventional kinesin, Kif1a, during G1-specific basal migration and cytoplasmic dynein during G2-specific apical migration. The strict coordination of motor ...