Dynamic molecular architecture and substrate recruitment of cullin3–RING E3 ligase CRL3Phosphatidylinositol 3-kinase α, a heterodimer of catalytic p110α and one of five regulatory subunits, mediates insulin- and insulin like growth factor-signaling and, frequently, oncogenesis. Cellular levels of ...
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Molecular architecture and assembly principles of Vibrio cholerae biofilms. Science 337, 236–239 (2012). Article CAS Google Scholar Drescher, K. et al. Architectural transitions in Vibrio cholerae biofilms at single-cell resolution. Proc. Natl Acad. Sci. USA 113, E2066–E2072 (2016). ...
Here, we used multi-task fMRI data from the Human Connectome Project to examine the spatiotemporal architecture of cognition in the human brain. By investigating the spatial, dynamic and molecular signatures of system-wide neural activity across a range of cognitive tasks, we show that large-...
The finding—that a given protein architecture dictates the global dynamic behavior of all members of a protein family—is general. This invites one to consider more broadly the consensual global dynamic behaviors of all protein fold families, such as those defined in the SCOP (Murzin et al., ...
In this paper we introduce the Dynamic Dual Modular Redundancy (DDMR) architecture. DDMR supports run-time scheduling of redundant threads, which has significant benefits relative to static binding. To allow dynamic pairing, DDMR replaces the special links with a novel ring architecture. DDMR ...
The SAM-related homeobox transcription-factor regulome presents an unprecedented opportunity to dissect the molecular mechanisms governing SAM maintenance and development, thereby advancing our understanding of maize growth and shoot architecture. Background ...
Molecular basis for photoreceptor outer segment architecture. Prog. Retin. Eye Res. 55, 52- 81. https://doi.org/10.1016/j.preteyeres.2016.05.003 Google Scholar Crossref PubMed Hamaoka, T., Takechi, M., Chinen, A., Nishiwaki, Y. and Kawamura, S. ( 2002). . Visuali...
Nonetheless, the extensive discrepancy between clinical and molecular data in humans and that obtained from other mammalian models prompted us to explore potential evolutionary divergences in chromatin architecture and related influences on transcription that could contribute to the AT-specific biology of ...
Molecular Input Line Entry System (SMILES) or structure-data file (SDF) format. During inference, the model randomly places the ligand, whose seed conformation is generated using RDKit26, around the protein. Then, over the course of 20 iterations (more details in “Model architecture”), ...