Protein-templated dynamic combinatorial chemistry (DCC) has emerged as a powerful method to identify new inhibitors given that it enables the protein to select its own best binder(s) from a library of interconverting compounds. Since the first report of DCC applied to the discovery of binders ...
Dynamic combinatorial chemistry (DCC) has proven its potential in drug discovery speeding the identification of modulators of biological targets. However, the exchange chemistries typically take place under specific reaction conditions, with limited tools capable of operating under physiological parameters. ...
In this dynamic combinatorial chemistry (DCC) sys- tem, the divergence is due to a combination of the assembly of diastereomeric macrocycles and a stereospecific electron-donor (D) – electron-acceptor (A) interaction, leading to structurally distinct pseudorotaxanes. These factors, combined with a...
DCC–nucleic acid templatingA combinatorial library that responds to its target by increasing the concentration of strong binders at the expense of weak binders sounds ideal. Dynamic combinatorial chemistry has the potential to achieve exactly this. In this review, we will highlight the unique ...
This long-awaited first book on this exciting new field in organic and supramolecular chemistry explains the fundamentals as well as possible applications of DCC. Authored by the "Who's Who" of DCC it spans the whole range of topics: catalysts, sensors, polymers, ligands, receptors, concluding...
Dynamic combinatorial chemistry (DCC) falls into the category of supramolecular chemistry and it utilizes covalent or noncovalent reversible reactions to generate dynamic combinatorial library (DCL) from building blocks with complementary functional groups [1], [2], [3], [4], [5], [6], [7], ...
dynamic chemistryenzymesinhibitorsprotein X‐ray crystallographyA new strategy that combines the concepts of fragment-based drug design and dynamic combinatorial chemistry (DCC) for targeting adenosine recognition sites on enzymes is reported. We demonstrate the use of 5'-deoxy-5'- thioadenosine as a ...
In this dynamic combinatorial chemistry (DCC) sys- tem, the divergence is due to a combination of the assembly of diastereomeric macrocycles and a stereospecific electron-donor (D) – electron-acceptor (A) interaction, leading to structurally distinct pseudorotaxanes. These factors, combined with a...
By combining the advantages of combinatorial chemistry and supramolecular chemistry, dynamic combinatorial chemistry may become a powerful tool for drug discovery and materials science. In their Perspective, [Lehn and Eliseev][1] chart some of the recent progress in this field. [1]: http://www.sc...
In this dynamic combinatorial chemistry (DCC) system, the divergence is due to a combination of the assembly of diastereomeric macrocycles and a stereospecific electron-donor (D)– electron-acceptor (A) interaction, leading to structurally distinct pseudorotaxanes. These factors, combined with a ...