Most of the response to the damage caused by Cbl deficiency seems to come from astrocytes and microglia, and is manifested as an increase in the number of cells positive for glial fibrillary acidic protein, the presence of ultrastructural signs of activation, and changes in cytokine and growth ...
Stationary adhesion of Borrelia is commonly observed at endothelial junctions of PECs, and translational motility of spirochetes seems to play an integral role in trans- endothelial translocation9. Spirochete interactions with endothelial cells, such as adhesion, crawling through inter- cellular space or...
Mitosis and meiosis both rely on cohesin, which embraces the sister chromatids and plays a crucial role for the faithful distribution of chromosomes to daughter cells. Prior to the cleavage by Separase at anaphase onset, cohesin is largely removed from chromosomes by the non-proteolytic action of ...
Protein dynamics appears to allow the use of either the cysteine or the serine residue in catalysis. This switchable dyad residue has not been previously reported for alphavirus nsP2 proteases and would have a major impact on the nsP2 protease as an anti-viral target....
Nanoparticle-sensitized photoporation is another efficient method that opens pores on cell surfaces to allow external cargo entry, capable of producing engineered T cells at a high throughput exceeding 105 cells per second. Lipid nanoparticles are commonly used for nucleic acid delivery because they ...