His426 is conserved in all bacterial DXPS but adopts a different conformation in theMtDXPS structure. Unlike most bacteria,M. tuberculosishas a serine at position 112 instead of a glycine or alanine. The serine at this position creates a steric restriction that prevents His426 from adopting its...
as even a 1% prevalence of such medicines for potentially fatal diseases, such as malaria, tuberculosis and HIV, is disastrous for individual patients.