Minimizing the size of dupilumab to scFv to increase its non-invasive permeability, which is determined by the size of the material, may allow it to be used as a non-invasive route of administration, such as a nasal spray rather than an injection. Recent single-cell RNA sequencing studies ...
DrugTargetMechanism of actionRoute of administrationStatusEndotype Omalizumab IgE Binds circulating IgE and prevents the interaction with high-affinity IgE receptor FcεRI Subcutaneous Approved by EMA and FDA T2-High Mepolizumab IL-5 Binds IL-5 and prevents the interaction with IL-5Rα on the surfa...
when added to guideline-based inhaled antiasthma treatment.45 This 6-month study, involv- ing 219 adult asthmatic subjects not adequately controlled by inhaled corticosteroids (ICS), evaluated the therapeutic activity of lebrikizumab given by the subcutaneous route every month at a dose of 250 mg...