Santini G, Mores N, Malerba M, Mondino C, Anzivino R, Macis G, et al. Dupilumab for the treatment of asthma. Expert Opin Investig Drugs. 2017;26:357-66.Santini G, Mores N, Malerba M, et al. Dupilumab for the treatment of asthma. Expert Opin Investig Drugs. 2017;26(3):357-366....
Expert opinion: Supported by a strategic mechanism of action, as well as by convincing preliminary clinical results, dupilumab currently appears to be a very promising biological drug for the treatment of severe uncontrolled asthma. It also may have benefits to comorbidities of asthma including atopic...
Dupilumab for the treatment of prurigo nodularis: A systematic review. PMID: 36742321 Dupilumab for the treatment of asthma. PMID: 28085503 Olfactory Outcomes With Dupilumab in Chronic Rhinosinusitis With Nasal Polyps. PMID: 34628065 Dupilumab in chronic rhinosinusitis with nasal polyposis: current status...
Dupilumabis a novel anti-cytokine biologic drug used in thetreatment of asthma. Therapies targeted at IL-4 and IL-13 are also beneficial in asthma treatments as they are Th2 cytokines that can stimulateeosinophilrecruitment and migration to local airways. IL-4 and IL-13 contributes to thepathop...
Background:Dupilumab is a monoclonal anti-IL-4Rα antibody developed for the treatment of severe asthma (SA). An early access programme for dupilumab was opened in France in SA patients experiencing unacceptable steroids side-effects and/or life-threatening exacerbations. Objective:To assess changes...
“Dupilumab treatment could enable patients with uncontrolled moderate-to-severe asthma to achieve a stringent and novel multicomponent endpoint representing clinical asthma remission,” the authors wrote. “Dupilumab substantially reduced exacerbations and improved lung function and asthma control in patients ...
Study Highlights Effect of Caffeine Intake While Pregnant on Childhood Asthma Phase 2 LB-102 Data, Advancing Treatment Landscape in Schizophrenia, with John Kane, MD Meta-Analysis Confirms Efficacy of Small Molecules for Psoriatic Arthritis Maternal caffeine consumption during pregnancy is linked to a ...
[4] Mario Castro, et al. N Engl J Med. Dupilumab Efficacy and Safety in Moderate-to-Severe Uncontrolled Asthma [5] Marlene Seegräber, et al. Expert Rev Clin Pharmacol. Dupilumab for treatment of atopic dermatitis AbMole奥默
2 With the latest approval, dupilumab now boasts more than a dozen approvals from the FDA, including indications as either an add-on or primary therapy for atopic dermatitis, asthma, chronic rhinosinusitis with nasal polyps, prurigo nodularis, or eosinophilic esophagitis. The FDA decision followed ...
those from phase 3 trials: age, sex, smoking habits, comorbid asthma and aspirin-exacerbated respiratory disease (AERD), previous endoscopic sinus surgery (ESS), hematic eosinophils and total IgE, NasalAQ2 Polyps Score (NPS), smell, SNOT-22, adverse events (AEs), and response to treatment. ...