Background and Objective: Current regulatory labeling recommends avoiding live vaccine use in dupilumab-treated patients. Clinical data are not available to support more specific guidance for live or live attenuated vaccines administration in dupilumab-treated patients. Methods: Children (6 months-5 years...
“live” vaccines, warfarin, and cyclosporine. Tell your doctor all medications and supplements you use. Dupixent During Pregnancy and Breastfeeding Tell your doctor if you are pregnant or plan to become pregnant before using Dupixent; it is unknown how it might affect a fetus. There is a ...
“live” vaccines, warfarin, and cyclosporine. Tell your doctor all medications and supplements you use. Dupixent During Pregnancy and Breastfeeding Tell your doctor if you are pregnant or plan to become pregnant before using Dupixent; it is unknown how it might affect a fetus. There is a ...
Vaccinations:Consider completing all age-appropriate vaccinations as recommended by current immunization guidelines prior to initiating DUPIXENT. Avoid use of live vaccines during treatment with DUPIXENT. ADVERSE REACTIONS: Most common adverse reactions are: ...
Non-Live Vaccines Immune responses to vaccination were assessed in a study in which subjects with atopic dermatitis were treated once weekly for 16 weeks with 300 mg of dupilumab (twice the recommended dosing frequency). After 12 weeks of Dupixent administration, subjects were vaccinated with a Tda...
Keri Holyoak, PA-C, MPH:No, I would agree. We don't advise live vaccines in conjunction with dupilumab. I always screen for parasitic infections or for those patients that travel to endemic areas with that being common. Melodie Young, MSN, RN, ANP-C:Perfect. ...
Live vaccines should not be administered while receiving Dupixent. Side Effects Dupixent side effects include conjunctivitis, blepharitis, oral herpes, keratitis, itchy eyes, other herpes simplex virus infection, dry eye, eosinophilia, injection site reactions, mouth or throat pain, problems sleeping, to...
Furthermore, we highlight an unmet need for research to determine how significantly dupilumab affects cellular and humoral immune responses to vaccination with live attenuated and inactivated vaccines.doi:10.1007/s40257-021-00607-6Sylvia A. Martinez-Cabriales...
Preclinical and clinical experience with dupilumab on the correlates of live attenuated vaccinesMichael E. Wechsler MD aAdelmir Souza-Machado MD, PhD bChristine Xu PhD cXuezhou Mao PhD cUpender Kapoor MD, DTCD cFaisal A. Khokhar MD d
Avoid coadministration with livevaccines CYP450 substrates The formation of CYP450 enzymes can be altered by increased levels of certain cytokines (e.g., interleukin [IL]-1, IL-6, IL-10, TNF-alpha, IFN) during chronic inflammation Dupilumab may modulate serum levels of some cytokines ...