Advise patients to read the FDA-approved patient information (medication guide). Advise patients to promptly report any manifestations of liver dysfunction (e.g., pruritus, dark urine, jaundice, right upper quadrant tenderness) to their clinician. Instruct patients that they should talk to their hea...
Duloxetine is not expected to decrease the metabolic clearance of drugs metabolised by CYP3A, 1A2, 2C9 or 2C19 to a clinically significant extent. However, it is a moderately potent inhibitor of CYP2D6; caution is necessary when coadministering duloxetine with other drugs that are predominantly...
Therefore, it is necessary to develop a rapid, reliable and sensitive method for the detection of mental drugs to monitor their concentration and to assist in the clinical guidance on medication use. Currently, most of the monitoring of the concentration of mental drugs is performed by liquid chr...
Specifically, duloxetine was calculated as having an incremental cost- effectiveness ratio of US$47,700 per QALY compared with desipramine, which was the reference medication against which the others were measured. While another cost- effectiveness analysis of open-label extension studies showed a...
Concomitant analgesics (NSAIDs, acetaminophen, opi- oids) were prohibited in 2 of the trials, other than as episodic rescue medication (short-acting analgesics only, ≤3 con- secutive days, ≤20 total days).14,17 The other 2 trials allowed patients who were on stable doses of NSAIDs ...
When, after 12 weeks, the patient is referred back to the GP, the GP is advised, through a Consultation Letter, to continue the medication for a duration of 6 months, as is advised in the 'NHG standard – depression' [81], a guideline for general practitioners. The GP will monitor pa...
When, after 12 weeks, the patient is referred back to the GP, the GP is advised, through a Consultation Letter, to continue the medication for a duration of 6 months, as is advised in the 'NHG standard – depression' [81], a guide- line for general practitioners. The GP will monitor...
EXPERT OPINION Duloxetine in the treatment of generalized anxiety disorder Trevor R Norman James S Olver Department of Psychiatry, University of Melbourne, Austin Hospital, Heidelberg,Victoria, Australia Abstract: Duloxetine, a medication with effects on both serotonin and noradrenaline transporter molecules...
Specifically, duloxetine was calculated as having an incremental cost- effectiveness ratio of US$47,700 per QALY compared with desipramine, which was the reference medication against which the others were measured. While another cost- effectiveness analysis of open-label extension studies showed a...