Duloxetine 40–80 mg/day (20–40mg twice daily) exhibited linear pharmacokinetics; steady-state plasma concentrations were achieved within 3 days. Duloxetine can be administered without regard to meals. Once absorbed, duloxetine undergoes extensive hepatic metabolism via cytochrome P450 (CYP) 2D6 and 1...
The intermediate dose of 40 mg bid was the same as that used in Studies 3 and 4 so that there would be a common refer- ence dose for inferring the relationship of the low dose in Studies 3 and 4 to the high dose in Studies 5 and 6. Study 5 showed that both duloxetine doses and...
First-bite syndrome (FBS) is manifested as acute and severe pain in the parotid region occurring at the first bite of a meal. While most cases of FBS arise
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