Depletion of integrin β4 reduced cell proliferation in both SUIT-2 and HPDE cells, reduced the number of SUIT-2 cells in S-phase, and induced G1 cell cycle arrest, suggesting a requirement for α6β4-mediated adhesion for cell cycle progression and growth. Taken together, these data ...
In this review, we discuss the recent advances regarding new functions of activated PSCs, including PSCs-cancer cells interaction, mechanisms involved in immunosuppressive regulation, and metabolic reprogramming. It’s clear that these updated experimental or clinical studies of PSCs may provide a ...
Others have shown that DLC1 loss is sufficient to promote a more migratory behavior of breast cancer cells [25]. Down regulation of ANGPT2 expression and a loss at 8p23.1 is also supported by Haverty and colleagues [6]. Over expression of this gene has been shown to degrade tumor ...
MCF10DCIS.com cells (referred as MCF10DCIS) express HSulf-2 and form comedo type DCIS and progress to IDC when transplanted in immune-deficient mice and, therefore, is an ideal model to study breast cancer progression. We evaluated the role of HSulf-2 in progression from DCIS to IDC ...
Empty Cell tumour infiltrating lymphocytes (TILs) T effector cells are divided into CD4 + T cells and CD8 + cells. The latter are the most studied in PDAC and are related to better survival. [184] OTSCs Empty Cell Regulatory T-cells Exert an immunosuppressive role, PDAC tumours ar...
erbB-2 overexpression in human mammary epithelial cells confers growth factor independence. Endocrinology 1999; 140: 3615–3622. 44 Enthammer M, Papadakis ES, Salome Gachet M, Deutsch M, Schwaiger S, Koziel K et al. Isolation of a novel thioflavin S-derived compound that inhibits BAG-1- ...
Given the expression of multiple different ligands and receptors from the Notch pathway in pancreatic cancer, and the role it has in the tumour cells and the microenvironment, it would be challenging to decide exactly which components of the pathway to target if not using a pan-Notch inhibitor....
Moreover, the exact role of tumor-associated myoepithelial cells in the DCIS-to-IDC development remains undefined. To address this, we explored the role of tumor-associated myoepithelial cells in the DCIS-to-IDC progression. We developed a direct coculture system to study the cell-cell ...
Diaz LK, Wiley EL, Venta LA (1989) Are malignant cells displaced by large-gauge needle core biopsy of the breast? AJR (Am J Roentgenol) 173(5):1303–1313 Stolier A, Skinner J, Levine EA (2000) A prospective study of seeding of the skin after core biopsy of the breast. Am J Sur...
Ascites-derived PDAC primary cells were isolated, cultured and characterised in ovo and in vitro. Results: We successfully established ascites-derived primary cell cultures within 2–7 days from 92% (93 out of 101) of the ascites fluid samples obtained (from 36 different patients). Homogeneous ...