Dabbs DJ, Ductal carcinoma of the breast: nuclear grade as a predictor of S-phase fraction Human Pathol 24(6): 251–256, 1993Dabbs DJ. Ductal carcinoma of breast: nuclear grade as a predictor of S-phase fraction. Hum Pathol. 1993;24(6):652-656....
Ductal invasive grade (G) 2 and G3 carcinomas represent the majority of invasive breast cancers. Previous morphological and cytogenetic studies have provided evidence that ductal invasive G2 carcinoma may originate from at least two different genetic pathways. The aim of this study was to evaluate...
Results:High MCT1 expression was more commonly found in TNBC compared to ER+ and/or PR+ and compared to HER-2+ (p< 0.001). Tumors with anin-situcomponent were less likely to stain strongly for MCT1 (p< 0.05). High nuclear grade was associated with higher MCT1 staining (p< 0.01)....
Intracellular localization of HuR is predominantly nuclear, but it shuttles between the nucleus and t... Heinonen,M. - 《Cancer Research》 被引量: 487发表: 2005年 Ductal invasive G2 and G3 carcinomas of the breast are the end stages of at least two different lines of genetic evolution ...
Noncalcified DCIS tended to have a nonhigh nuclear grade and was frequently the noncomedo type. In addition, c-erb-B2 was more commonly expressed in calcified DCIS. Conclusions. Imaging findings for noncalcified DCIS are relatively nonspecific and are frequently similar to those of invasive ...
HER2-positive DCIS was previously estimated at > 50 %, occurring primarily in ER-negative, comedo-type DCIS of high nuclear grade. There has been no documented centralized multi-institutional HER2 analysis of DCIS. NSABP B-43 provides a unique opportunity to evaluate this in a large cohort of...
Nuclear grade has been associated with breast DCIS recurrence and progression to invasive carcinoma; however, our previous study of a cohort of patients with breast DCIS did not find such an association with outcome. Fifty percent of patients had heterogeneous DCIS with more than one nuclear grade...
The pathologic result was intermediate - nuclear - grade invasiveductalcarcinoma. 病理结果为核中等分化的导管癌. 互联网 This is infiltratingductalcarcinoma of breast. 乳腺浸润性导管癌. 互联网 On biopsy, this was an infiltratingductalcarcinoma.
Compared to DCIS, TC exhibited favorable clinicopathologic characteristics such as a lower nuclear grade (92.3%), higher expression of hormonal receptors (estrogen receptor-positive, 92.9%; progesterone receptor-positive, 87.0%), and less frequent overexpression of human epidermal growth receptor 2 (...
and micropapillary subtypes.4Based on the histopathologic nuclear features, DCIS can present as a spectrum, with low-grade (I), intermediate-grade (II), and high-grade (III) lesions; the latter are associated with a higher likelihood of invasive ductal carcinoma (IDC).5,6DCIS is commonly co...