Several classifications of DCIS based on nuclear grade and necrosis have been shown to stratify DCIS into subtypes associated with vastly different risks of local recurrence and invasive transformation. Breast-conserving therapy for DCIS is dependent on adequate surgical excision, even more so than for...
nuclear gradelocal recurrencesThe clinical significance of micropapillary growth pattern in ductal carcinoma in situ is controversial and the impact of nuclear grading in terms of recurrence of this lesion is yet to be clarified. Our aim was to evaluate, on a series of micropapillary in situ ...
family history, nuclear grade, comedo-type necrosis, tumor size and margin width. With the addition of radiation therapy to excisional surgery, there is a 50% reduction in the overall local
There are a variety of prognostic factors in DCIS, which belong to clinical and histopathologic features such as patient age, the extent of DCIS, nuclear grade, comedo necrosis, multifocality, margin status, and mode of presentation14. Among them, nuclear grade and comedo necrosis are the stron...
The pathologic result was intermediate - nuclear - grade invasiveductalcarcinoma. 病理结果为核中等分化的导管癌. 互联网 This is infiltratingductalcarcinoma of breast. 乳腺浸润性导管癌. 互联网 On biopsy, this was an infiltratingductalcarcinoma.
In addition, omission of RT, margin width ≤4 mm and high nuclear grade were also significant predictors of local recurrence. Specifically, the increased risk of local recurrence associated with multifocality was only observed in women who did not receive RT. No association was found between ...
Baas2, Elsken van der Wall2 and Ivette A. G. Deckers3 Abstract Background: Histologic grade of ductal carcinoma in situ of the breast (DCIS) may become the single biomarker that decides whether patients will be treated. Yet, evidence shows that grading variation in daily practice is ...
nuclear grade and secondarily on necrosis.11Features recorded included pathologic size, histologic pattern, nuclear grade, and presence of necrosis. DCISM was diagnosed on the basis of clear or suspected microinvasion of carcinoma cells into stromal tissue outside defined mammary ducts and ...
Of note, we found no statistically significant relationship between age and DCIS architectural pattern, nuclear grade, comedo necrosis or expression of estrogen receptor, progesterone receptor or human epidermal growth factor receptor 2. We conclude that DCIS in younger women is more often symptomatic,...
Table 2 Influence of pre-operative surgery on axilla surgery (% of patients) Sentinel node biopsy Axillary dissection No biopsy 15.4 14 Previous biopsy 25 8.2 P-value o0.0001 0.0009 Tumour size, nuclear grade, necrosis and age significantly influenced treatment modalities (Table 3). Mastectomy was...