采用划痕和Transwell侵袭实验检测DTX2基因的表达改变对CRC细胞迁移侵袭能力的影响,并通过Western blotting检测各组中Notch2,NICD,Akt,p-AKT,MMP-2及MMP-9蛋白的表达水平.CRC细胞共转染pcDNA-DTX2和Notch2 siRNA,检测回复实验对CRC细胞迁移侵袭能力的影响.结果CRC细胞中DTX2 mRNA和蛋白表达量,敲低组中明显降低(P<...
DTX1在信号转导通路中的作用除了细胞周期调控外，DTX1还在多种信号转导通路中发挥着重要作用。例如，DTX1可以调控Notch信号通路，影响细胞的增殖和分化过程。此外，DTX1还参与了Wnt信号通路、TGF-β信号通路等多种重要信号传递通路的调节。通过对这些信号通路的调控，DTX1影响了细胞的命运决定和功能表达。总结综上所述...
Cat No.18350-1-AP Freight/Packing:-- Country/Region Please contact our China branch Proteintech Guarantee Request bulk or custom quote Deltex homolog 1 (E3 ubiquitin-protein ligase DTX1) is a regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a ...
72 The human NOTCH1 gene was first identified in T-ALL patients with the translocation t(7;9)(q34;q34.3), causing TCRβ-driven expression of a truncated activated form of NOTCH1 (TAN1).73 However, this translocation occurs in less than 1% of T-ALL cases, whereas activating mutations ...
DTX4 is a regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. It functions as an ubiquitin ligase protein in vivo, mediating 'Lys48'-linked polyubiquitination and promoting degradation of TBK1, targeting ...
Notch信号调节剂,Notch信号调节剂,一种参与细胞间通信的信号传导途径,可调节多种细胞命运决定(通过相似性)。 在体内起泛素连接酶蛋白的作用,介导“ Lys48”连锁的泛素化并促进TBK1降解,靶向TBK1需要与NLRP4相互作用。 功能: Notch信号调节剂,一种参与细胞间通信的信号传导途径,可调节多种细胞命运决定。 可能同时充当...
基因别名:DTX2; KIAA1528; RNF58 UniProt ID:(Human) Q86UW9 Entrez Gene ID:(Human) 113878 功能 protein bindingzinc ion bindingligase activityubiquitin-protein ligase 参与通路 Notch signaling pathwayprotein ubiquitination
DTX1 基因简介 中英文全称:deltex 同源物1(果蝇) deltex homolog 1 (Drosophila) 分布:细胞质 活性:转录辅激活蛋白|Notch 结合|蛋白结合 |锌离子结合|转录调控因子|金属离子结合 参与:转录自 RNA 聚合酶II 启动子|调控Notch 信号转导途径|负调控 神经元分化...
DTX3充当E3泛素连接酶(Takeyama等,2003 [PubMed 12670957])。 功能: Notch信号调节剂,一种参与细胞间通信的信号传导途径,可调节多种细胞命运决定。 可能同时充当Notch的正负调节剂,具体取决于发育和细胞环境(通过相似性)。 在体外起泛素连接酶蛋白的作用,表明它可能通过某种泛素连接酶活性调节Notch途径。 本产品仅用...
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