Biosynthesis of the nucleotide sugar precursor dTDP-L-rhamnose is critical for the viability and virulence of many human pathogenic bacteria, including Streptococcus pyogenes (Group A Streptococcus; GAS) and Streptococcus mutans. Those pathogens require dTDP-L-rhamnose for the production of structurally ...
The rfbc gene located within the rfb gene cluster encoded the dTDP-rhamnosyl transferase RfbF, which was involved in the dTDP-L-rhamnose biosynthesis. L-Rhamnose is the receptor on the LPS core for the attachment of O polysaccharides43, it is an indispensable component of the lipopolysaccharide...
Homologs of the Rml Enzymes from Salmonella enterica Are Responsible for dTDP-β-l-Rhamnose Biosynthesis in the Gram-Positive Thermophile Aneurinibacillus ... The glycan chains of the surface layer (S-layer) glycoprotein from the gram-positive, thermophilic bacterium Aneurinibacillus (formerly Bacillus...
Biosynthesis of streptomycin dTDP-Dihydrostreptose synthase from Streptomyces griseus and dTDP-4-keto-l-rhamnose 3,5-epimerase from S. griseus and Escherichia coli Y10Author(s): Hans Peter Wahl , Hans Grisebach Publication date Created: May 1979 Publication date (Print): May 1979 Journal: ...
Homologs of the Rml Enzymes from Salmonella enterica Are Responsible for dTDP-β-l-Rhamnose Biosynthesis in the Gram-Positive Thermophile Aneurinibacillus ... ylyltransferase (RmlA), dTDP-D-glucose 4,6-dehydratase (RmlB), dTDP-4-dehydrorhamnose 3,5-epimerase (RmlC), and dTDP-4-dehydrorhamnos...
Marolda,C.L. and Valvano,M.A. (1995) Genetic analysis of the dTDP-rhamnose biosynthesis region of the Escherichia coli VW187 (O7:K1) rfb gene cluster: identification of functional homologs of rfbB and rfbA in the rff cluster and correct location of the rffE gene. J. Bacteriol., 177,...
dTDP-6-deoxy-L- lyxo-4-hexulose reductase (RmlD) catalyzes the final step in the conversion of dTDP-D-glucose to dTDP-L-rhamnose in an NAD(P)H- and Mg 2+-dependent reaction. L-rhamnose biosynthesis is an antibacterial target. The st...
Homologs of the Rml enzymes from Salmonella enterica are responsible for dTDP--L-rhamnose biosynthesis in the gram-positive thermophile Aneurini- bacillus thermoaerophilus DSM 10155. Appl. Environ. Microbiol. 68:3708- 3715.Graninger, M., Kneidinger, B., Bruno, K., Scheberl, A. and ...
Biosynthesis of dTDP-3-acetamido-3,6-dideoxy-α-D-galactose in Aneurinibacillus thermoaerophilus L420-91[sup T]. well studied dTDP-L-rhamnose biosynthetic pathway, namely D-glucose-1-phosphate thymidyltransferase (Rm1A) and dTDP-D-glucose-4,6-dehydratase (Rm1B). ... Pfoestl,Andreas,Ho...
Cooperating of kaempferol and dTDP-alpha-L-rhamnose biosynthesis.Xun YueXinQi GaoFang WangYuXiu DongXingguo LiXian Sheng Zhang