The Ihara epileptic rat (IER) is a mutant model with limbic-like seizures whose pathology and causative gene remain elusive. In this report, via linkage analysis, we identified Down syndrome cell adhesion molecule-like 1(Dscaml1) as the responsible gene for IER. A single base mutation in ...
However, the underlying molecular pathology nor the responsible gene for IER has been clarified. DSCAML1 (Down Syndrome Cell Adhesion Mole- cule Like 1) is a transmembrane protein with ten immu- noglobulin (Ig) and six fibronectin type III domains [7], whose structure is similar to its ...
DSCAML1mutationsneurodevelopmental disorderThe molecular mechanisms underlying neurodevelopmental disorders (NDDs) remain unclear. We previously identified Down syndrome cell adhesion molecule like 1 (Dscaml1) as a responsible gene for Ihara epileptic rat (IER), a rat model for human NDDs with epilepsy....
DSCAML1mutationsneurodevelopmental disorderThe molecular mechanisms underlying neurodevelopmental disorders (NDDs) remain unclear. We previously identified Down syndrome cell adhesion molecule like 1 (Dscaml1) as a responsible gene for Ihara epileptic rat (IER), a rat model for human NDDs with epilepsy....