If the acid concentration during the salt formation is more than 5.0% then acetone quantity as the residual solvent in the reaction product is found to be greater than 0.5% in our hands which is above the ICH limits. If acid concentration during the salt formation is less than 1.8%, then...
The process requires large quantity of reducing agent viz., for reducing one lg of compound about 5g of reducing agent is required which is not conducive for industrial production. Chinese patent application no. CN 102952001 discloses a process for the preparation of (lR,2R)cyclohexane-l,2-...
37 Further research should investigate the effects of restrictions such as formulary placement and quantity limits. Although preferred drug lists can be associated with use ratios, unmeasured factors related to patient preference, physician familiarity, and other Medicaid policies may also contribu...
Maintenance dose: May be given by injection into tubing or by IV infusion with an appropriate quantity of fluid Comments:There is clinical evidence to suggest this drug may have a beneficial effect in the control of the neuromuscular manifestations of tetanus. This drug should not replace the us...
Prescribe in smallest quantity consistent with good patient management to reduce risk of overdosage. Neuroleptic Malignant Syndrome Neuroleptic malignant syndrome (NMS), a potentially fatal syndrome requiring immediate discontinuance of the drug and intensive symptomatic treatment, reported rarely. ...
The Transparency Commission conducts an assessment of the improvement in the Medical Service Rendered (Service medical rendu) in terms of the effectiveness of the drug (quantity of effect), adverse effects, existing of alternative options, and its relevance to public health. Reimbursement decisions ...
thereby reducing the quantity of activated lymphocytes in the tissue. The exact mechanism is unknown. Interestingly, the effect shows some degree of selectivity, as a greater reduction was observed in the case of cells associated with the adaptive immune response, which are known to play a role ...
The quantity of API, that is the dose, is also an important factor, since it determines the size and volume of the finished dosage form. A short overview of options for oral drugs and considerations and data informing formulation choices is provided below with key advantages and disadvantages ...
cough is suffocating and painful. This is the reaction of the human body to the feces of the mucous bronchi. First, the cough is dry, but later the sputum begins to secrete. Its quantity is insignificant and the color is transparent. Later its volume increases, it becomes foamy, and chang...
Since the number of drugs included each year varies, the average values of DDDs, annual drug cost, and DDDc for the drugs involved in each year were taken to more accurately measure the overall drug utilization each year and eliminate the influence of quantity differences on the results. It ...