Losartan is used to treat high blood pressure (hypertension). It is also used to lower the risk of stroke in certain people with heart disease.
Sublocade (extended-release buprenorphine injection) is used to treat adults with moderate to severe addiction (dependence) to opioid drugs (prescription or illegal) who:have started treatment with a single dose of a buprenorphine medicine in the form of a sublingual tablet or buccal film (...
It is also used to treat breast cancer, neuroblastoma, and rhabdomyosarcoma. While it is occasionally applied to malignant melanoma, melphalan is not enriched in melanocytes, despite the role of phenylala- nine as a precursor in the synthesis of Melanin. Administra- tion is oral or intravenous....
FDA approval information for accelerated approval drugs used to treat hematologic malignancies. Drug Name Indication Time to Approval (Months) N in Trial Overall Response Rate (%) Alemtuzumab CLL 16.5 93 33 Bortezomib Myeloma 3.7 188 14 Cytarabine liposomal Lymphomatous meningitis 5.5 17 41 Denileuk...
alpha tubulin. The wide range of proteins affected by the many different HDAC enzymes, coupled with the many new drugs now targeting this biology, suggests we may only be at the beginning in figuring out how to manipulate the ‘acetylome’ in a fashion that will both prevent and treat ...
orphan drug designation was assigned also in the E.U. the same year. In 2012, fast track designation was assigned by the FDA for the treatment of CLL. In 2013, breakthrough therapy designations were assigned to the compound in the U.S.: for the treatment (as monotherapy) of patients wi...
useful to treat solid tumors such as: breast, colon, lung and prostate tumors; and liquid tumors such as lymphomas and leukemias. As used herein, MDM2 means a human MDM2 protein and p53 means a human p53 protein. It is noted that human MDM2 can also be referred to as HDM2 or hMDM2...
We assessed overall survival benefit as confirmed if there was a significant increase in overall survival in the trial’s primary intention-to-treat cohort. We characterized quality-of-life benefit as confirmed if there was a significant increase in a validated and prespecified global quality-of-...
Calquence (acalabrutinib) is used to treat chronic lymphocytic leukemia (CLL), and mantle cell lymphoma. Includes Calquence side effects, interactions and indications.
Xgeva is also used to treat giant cell bone tumor in adults and teenagers with fully matured bone structure. Xgeva is also used to treat high blood levels of calcium caused by cancer, when other medicines such as pamidronate or zoledronic acid (Zometa) have been used without success. ...