Diminished. In addition, the weight of Gpbar1-deficient female mice bred with high-fat diet significantly increased compared to wild-type mice, which was due to increased fat. This suggests that Gpbar1 contributes to the control of bile acid homeostasis and lipid metabolism. 展开 ...
Pretreatment of the rats with phenobarbital resulted in a considerable increase of the drug-oxidizing enzymes even during the period of rapid growth. The possibility that the changes of drug-oxidizing capacities of regenerating liver are related to the rate of liver growth is considered. 展开 关键...
Wegovy was superior to placebo in mean percent change in BMI at week 68 (16.1% decrease vs 0.6% increase) - the primary endpoint. In addition, the percent of children with a BMI reduction of at least 5% was 77% in the Wegovy group vs. 20% in those receiving a placebo. Body weight ...
Mild renal impairment (eGFR 60 to <90 mL/minute): Peak plasma concentrations or systemic exposure of nirmatrelvir increase by 30 or 24%, respectively, following administration of ritonavir-boosted nirmatrelvir.Moderate renal impairment (eGFR 30 to <60 mL/minute): Peak plasma concentrations or ...
small and large intestinal monolayers, that small intestinal monolayers have greater CYP3A activity, and that the hydroxylated metabolite (4-OHCP) is only generated in small intestinal monolayers, which indicate that CP-induced small intestinal toxicity is due to metabolism of CP to its active state...
Concomitant administration of agents increasing the rate of cyclosporin metabolism (e.g. anticonvulsants, antitubercular antibiotics) may result in decreased trough cyclosporin concentrations. The third possible outcome is increased or additive nephrotoxicity and appears to involve agents with known nephro...
(Passamonti and Mora2023). This leads to inflammation and fibrosis and to hyperactivation of the activin A receptor type I (ACVR1), which results in increased expression of hepcidin and impaired iron metabolism (Chifotides et al.2022; Verstovsek et al.2023).Momelotinibis a small molecule...
Several anoretic drugs affect dopamine metabolism in the rat striatum, increasing the concentration of homovanillic acid (HVA). However l- and d-amphetamine and mazindol develop a tolerance to increase. On the contrary, the effect of fenfluramine and S 992 is not reduced by sub-chronic treatmen...
The way Jardiance works to reduce the risk of cardiovascular or heart failure is thought to be related to changes in heart muscle metabolism from favoring the use of glucose to using a more balanced combination of fatty acids, ketone bodies (ketone), branched-chain amino acids (BCAA) and ...
In patients with hepatic impairment, metabolism and clearance are decreased.In patients with end-stage renal disease (requiring dialysis), plasma half-life may be unchanged; in patients with mild to moderate renal impairment (Clcr 30–80 mL/min), there is no clinically important effect on ...