Little, Drugs that increase gamma-aminobutyric acid transmission protect against the high pressure neurological syndrome, Br. J. Pharmacol. 76 (1982) 447-452.Bichard, A.R. & Little, H.J. ( 1982 ). Drugs that increase GABA transmission protect against the HPNS . Br. J. Pharmac. , 76 ...
stimulant: drug that tends to increase overall levels of neural activity; includes caffeine, nicotine, amphetamines, and cocaine tolerance: state of requiring increasing quantities of the drug to gain the desired effect withdrawal: variety of negative symptoms experienced when drug use is discontinuedLic...
Inform patients that they may experience loss of consciousness or altered state of consciousness during brexanolone infusion and that concomitant use of other CNS depressants, such as opiates or benzodiazepines may increase the risk or severity of sedative effects. Advise patients to report signs of...
CDP treatment impaired the performance of controls, as shown by an increase in the number of errors, while CDP improved performance in malnourished rats, as shown by a reduction in the number of errors. It was suggested that the overreaction to stress in the malnourished animals could affect ...
stimulant:drug that tends to increase overall levels of neural activity; includes caffeine, nicotine, amphetamines, and cocaine tolerance:state of requiring increasing quantities of the drug to gain the desired effect withdrawal:variety of negative symptoms experienced when drug use is discontinued ...
These drugs alter the levels of neuromodulators such as 5-hydroxytryptamine (5-HT), dopamine, norepinephrine, glutamate, and γ-aminobutyric acid (GABA) in the brain and influence neuronal activity [6,7]. Emerging evidence shows that neuronal activity in the tumor microenvironment can promote the...
Medicines that interact with diazepam may either decrease its effect, affect how long it works, increase side effects, or have less of an effect when taken with diazepam. An interaction between two medications does not always mean that you must stop taking one of the medications; however, ...
Recent studies have shown that a chronic decrease in GABA function in the SN, through the destruction of stria-tonigral pathways 16,17 , produces an increase in the number of GABA binding sites in the SN 14,45 . Therefore, if a relative deficit of GABA transmission in the SN were to ...
neuronal activity. When Benzo’s are introduced to the body they cause an increase GABA activity resulting in the slowing of the nerve impulses throughout the entire body. The body has two types of receptors that respond to GABA. One results in providing anti-anxiety and the second in ...
Rational antiepileptic drug design for such a complex disease would probably benefit from focus on the development of multi-target drugs that increase efficacy and reduce treatment resistance. Padsevonil, an antiepileptic drug currently in clinical research phase, stands out as one of the few ...