Similarly, the JAK inhibitors ruxolitinib and tofacitinib and the proteasome inhibitors bortezomib and carflizomib are part of two independent clusters that contain no other drugs. Two of three antidiabetics, rosiglitazone and saxagliptin are part of a smaller cluster that first merges with a cluster...
However, many new drugs are already showing significant single-agent activity in MM in phase 1 and 2 clinical trials, and hence there is a high likelihood that they will be eventually approved for the treatment of the disease in the near future. The development of these agents for regulatory...
Two in particular are highlighted below, including a new β-lactam/β-lactamase inhibitor (BLIBLI) showing success with urinary tract infections (UTIs) and a novel approach to Clostridioides difficile infection (CDI) that may reduce the rate of recurrence. CERTAIN-1 With 19% of Enterobacte...
In Ufasomes, the fatty acid molecules are aligned so that their hydrocarbon tails are directed towards the inside of the membrane and the carboxyl groups come into interact with water. A stable Ufasome formulation crucially relies on the correct selection of fatty acid, the amount of cholesterol...
Zika virus (ZIKV) is an emerging pathogen that has been associated with large numbers of cases of severe neurologic disease, including Guillain-Barré syndrome and microcephaly. Despite its recent establishment as a serious global public health concern t
We review current knowledge on the SARS-COV-2/host interactome cascade involved in the viral pathogenicity through the graph theory concept and highlight the hub proteins in the intra-viral network that create a subnet with a small number of host central proteins, leading to cell disintegration ...
in combination with chemotherapy or other biological agents. They are easy to administer and are generally well tolerated with minimal side effects. Different dosing levels and schedules and the use of isospecific HDAC inhibitors are some of the strategies that are being employed to increase the ...
Can you imagine such a thing, a man in Texas with a web site that explains Texas bank looting better than any in the world and guess what? He is having the same kind of uncommon problems keeping his site up as I do. Yesterday my site received a low of 38 visitors --- none from ...
Customer value is created by constantly providing great end-to-end supply chain solutions that address even the most complicated requirements of our clients. We are always progressing and upgrading in terms of pharmaceutical hospital supply. ...
This was activated by 1,1 -carbonyldiimidazole (CDI) and coupled with sulfonamide 28 to afford acyl sulfonamide 29, which was used in the last step, the nucleophilic addition of pyrrolidine salt 30 in the presence of potassium carbonate to produce elexacaftor (31). The authors claim that the...