"We then wanted to learn if drugs that interfere with the receptor and block estrogen's ability to bind to it could be used to treat or prevent cervical cancer," he says. Chung turned to an ER alpha blocker used to treatbreast cancer, fulvestrant, and tested it on the HPV-positive mice...
Whilecancer cellshave reduced DNA repair function, they need this function to survive and replicate. PARP inhibitors are drugs that block an enzyme that repairs DNA, called poly adenosine diphosphate-ribose polymerase, abolishing cancer cell's ability to repair DNA altogether and delivering a fatal b...
Replacement of the female hormones (estrogen and progesterone) lost during menopause. Replacement may be of either or both hormones. Studies have suggested that this may increase breast cancer risk and HRT use has dropped as a result. Hormone Therapy Drugs Hormone Blocking Agents that interfere ...
Estrogen receptors, for example, are all over the brain and are responsible for upregulating hundreds of genes involved in all sorts of brain activity, not just those involved in the development of sex characteristics or reproduction. These hormones are so important to brain function, that the bra...
Adnane, L., Trail, P. A., Taylor, I., Wilhelm, S. M. Sorafenib (BAY 43–9006, Nexavar), a dual-action inhibitor that targets RAF/MEK/ERK pathway in tumor cells and tyrosine kinases VEGFR/PDGFR in tumor vasculature.Methods Enzymol.407, 597–612 (2005). ...
toxic dopamine levels accumulate in the terminal end of the neuron causing neuron cell death. Dopamine is a mitochondrial toxin and inhibits Complex I of the mitochondrial respiratory chain. Males are more susceptible to this adverse effect, compared to females protected by higher estrogen levels. (...
SERMs or SERDs work to either block the estrogen receptors (ER) so that estrogen cannot have an effect to fuel the cancer, or both block and destroy the estrogen receptor.Orserdu, the latest approved SERD, works by blocking the effect of estrogen on the hormone receptor-positive breast ...
R. A transmembrane intracellular estrogen receptor mediates rapid cell signaling. Science 307, 1625–1630 (2005). Article CAS PubMed Google Scholar Chulia, S. et al. Relationships between structure and vascular activity in a series of benzylisoquinolines. Br. J. Pharmacol. 122, 409–416 (1997...
The proliferation of targeted anticancer agents over the last two decades has revolutionized cancer treatment and improved survival in many previously refr
Dosage of lamotrigine depends on whether valproate, glucuronidation-inducing anticonvulsant drugs (e.g., carbamazepine, phenobarbital, phenytoin, primidone), other drugs that induce lamotrigine glucuronidation (e.g., rifampin, estrogen-containing oral contraceptives, lopinavir/ritonavir, atazanavir/ritonavir),...