This chapter discusses the different aspects of drugs affecting enzyme systems. Drugs that affect enzyme systems continue to play an increasingly important part of contemporary pharmacodynamics. The greatest effort is being directed toward studies of the enzyme tyrosine hydroxylase, which represents the ...
Angiotensin-I Converting Enzyme Inhibitors as Potential Anti-Angiogenic Agents for Cancer Therapy Angiotensin-I converting enzyme inhibitors (ACE-Is) are commonly used as safe antihypertensive agents, and it has recently been suggested that they decreas... H Yoshiji,S Kuriyama,R Noguchi,... - 《Cu...
and chronic dosing are determined. Acute toxicity is less important as long as LD50 (the dose that kills 50% of animals) is not close to the ED50 (the dose causing 50% of maximum pharmacological response). 与药物功效的药理学实验类似,其用药的急慢性毒副作用须被确定。只要LD50(导 致50%实验...
This review describes key principles and approaches for the reliable determination of enzyme activities and inhibition as well as some of the methods that are in current use for such studies with these two enzymes. Their applicability and potential pitfalls arising from their inappropriate use are ...
Table 4 presents the predicted change in annual days supplied when co-payments are doubled for people with 1 of 8 chronic conditions. Medications with OTC substitutes included NSAIDs, antihistamines, and antiulcerants (H2 receptor antagonists and proton pump inhibitors). We found that a doubling ...
The enzymatic cycle of glucose oxidases (GOx) and the production of hydrogen peroxide.In the above system, GOx which is a flavin adenine dinucleotide (FAD)-dependent enzyme oxidises β-d-glucose to gluconolactone through a process that involves the transfer of two protons and two electrons from...
HPPD herbicides are one of the two types of 'bleaching' herbicides being inhibitors of hydroxyphenylpyruvate dioxygenase. Today it is known that inhibition... V Almsick,Andreas - 《Outlooks on Pest Management》 被引量: 18发表: 2009年 Combined use of enzyme inhibitors and pharmaceutical preparation...
medications that are potent inhibitors of CYP3A4 such as ketoconazole or ritonavir nitrates such as isosorbide dinitrate, isosorbide mononitrate, and nitroglycerin; and amyl nitrite are contraindicated. others, such as aprepitant, cyclosporine, or imatinib. ...
These edible marine invertebrates are sources of potent bioactive peptides. The last two decades have seen a surge of interest in the discovery of antioxidant peptides from edible marine invertebrates. Enzymatic hydrolysis is an efficient strategy commonly used for releasing antioxidant peptides from ...
E. What is the evidence that oxcarbazepine and carbamazepine are distinctly different antiepileptic drugs? Epilepsy Behav. 5, 627–635 (2004). Article PubMed Google Scholar Greenberg, R. M. Are Ca2+ channels targets of praziquantel action? Int. J. Parasitol. 35, 1–9 (2005). Article CAS...