Assessing a drug for efficacy and safety in heart failure is a challenging task (Guyatt, 1986). For example, six compounds have been considered by the US Food and Drug Administration (FDA) during the 1980s: captopril, enalapril, amrinone, milrinone, lisinopril and isosorbide dinitrate. However,...
治疗心力衰竭的药物 (DrugsUsedInHeartFailure)心力衰竭（heartfailure,HF）:由于任何原因的初始心肌损伤（心肌梗死、血液动力负荷过重、炎症），引起心 肌结构和功能的变化，最后导致心室射血/ 充盈功能低下。ChronicHeartFailure(CHF)发病率1%～4%，高龄者达10%。心功能为NYHAⅡ～Ⅲ级者年死亡率 约10%～20%，Ⅳ...
Over the last decades, pharmacological treatment of patients hospitalized for acute decompensated heart failure have remained unchanged. Virtually all patients are treated with a loop diuretic, and the use of additional drugs depends on the type of heart failure and mainly on blood pressure. Only in...
These drugs have proven effect in heart failure, but patients with kidney disease were excluded from clinical trials due to fear of kidney complications. Whilekidney complicationsare still a potential concern, this new study, which is presented at the annual congress of the European Society of Card...
Acute heart failure (AHF) is a major burden disease, with a complex physiopathology, unsatisfactory diagnosis, treatment and a very poor prognosis. In the
and the associated increase in mortality [2]. Hence, there is a clear unmet need to more effectively target cardiac damage in diabetes to protect against heart failure. A major impediment to developing drugs for HFpEF i...
The Combined Empagliflozin and Sacubitril/Valsartan Therapy Attenuates Isoproterenol-Induced Heart Failure in Rats: Functional, Molecular, and Structural Insights Maja Muric Ivan Srejovic Vladimir Jakovljevic Original Article 06 February 2025 Safety Analysis of Spironolactone Use in Patients Undergoing Percu...
(HealthDay)—Diabetes drugs containing saxagliptin and alogliptin may raise the risk of heart failure, particularly in patients with heart or kidney disease, U.S. health officials warned Tuesday. Drugs containing these ingredients are Onglyza (saxagliptin), Kombiglyze XR (saxagliptin and metformin exten...
Farxiga (dapagliflozin) is an oral prescription medication that may be given to certain adults with diabetes, heart disease, or kidney disease to improve their outcomes. It may also be given to children aged 10 years and older with type 2 diabetes.
heart failure in vulnerable individuals. Although NSAID-related cardiotoxicity is relatively rare and most commonly seen in elderly individuals with concomitant disease, the widespread long-term use of these drugs in risk groups is potentially hazardous. Pending comprehensive safety analyses, the use of ...