P4-406: Tarenflurbil (MPC-7869), a selective Aβ42-lowering agent, has no significant effect on drugs metabolized by CYP2C9Background: Alzheimer's disease is the most common type of dementia among the elderly. Its histopathologic features include phosphorylated Tau neurofibrillary tangles and ...
Drugs metabolized by CYP2C9: possible increased plasma concentrations.Specific DrugsDrug Interaction Comments Warfarin Potential for increased plasma warfarin concentrations with intravaginal miconazole Potential for interaction with miconazole applied topically to skin is unknown Do not use intravaginal ...
Metabolized by CYP isoenzymes, mainly CYP2C9. CYP3A4, uridine diphosphate-glucuronosyltransferase (UGT) 2B7, and CPY2C8 may contribute to metabolism.Drugs Affecting Hepatic Microsomal EnzymesCYP2C9 inhibitors: Possible increased systemic exposure to diclofenac and risk of adverse effects. Dosage ...
21 For intermediate metabolizers with an activity score of 1, meloxicam can be initiated with 50% of the lowest recommended dose with close monitoring, or an alternative NSAID that is not metabolized by CYP2C9 should be used.21 For piroxicam, which has a half-life even longer than ...
Bosentan is metabolized by cytochrome P450 (CYP) 2C9 and CYP3A4 into three metabolites, Ro 48-5033 (major metabolite), Ro 47-8634, and Ro 64–1056. Only Ro 48–5033 is metabolically active, accounting for up to 20% of drug activity. Oral bosentan is eliminated largely via feces in he...
After either oral or intravenous administration of 14 C irbesartan, about 20 % of the radioactivity is recovered in the urine, and the remainder in the faeces. Less than 2 % of the dose is excreted in the urine as unchanged irbesartan. Hydrochlorothiazide is not metabolized but is ...
Concurrent administration of Linezolid does not substantially alter the pharmacokinetic characteristics of (S)-warfarin, which is extensively metabolized by CYP2C9. Drugs such as warfarin and phenytoin, which are CYP2C9 substrates, may be given with Linezolid without changes in dosage regimen....
administration of 14 C irbesartan, about 20% of the radioactivity is recovered in the urine, and the remainder in the faeces. Less than 2% of the dose is excreted in the urine as unchanged irbesartan. Hydrochlorothiazide is not metabolized but is eliminated rapidly by the kidneys. At least...
Present in plasma largely as unchanged drug (96 to 99%). Metabolized primarily by hydroxylation, O-demethylation, and conjugation. Also metabolized by CYP2C9 and CYP2D6.Elimination RouteExcreted in feces. Urinary elimination negligible (<0.3% of the dose)....
Primarily metabolized by CYP2C9.Inhibits CYP2D6; does not inhibit CYP2C9, CYP2C19, or CYP3A4.Drugs Affecting or Metabolized by Hepatic Microsomal EnzymesCYP2C9 inhibitors (e.g., fluconazole): Possible increased celecoxib exposure and toxicity. Celecoxib dosage adjustment may be required....