Metabolized mainly by CYP2B6 and to a lesser extent by CYP2C9.Inhibits CYP isoenzymes 1A1, 1A2, 2B1, 2C9, 2D6, 2E1, and 3A4.Drugs Metabolized by or Affecting Hepatic Microsomal EnzymesPossibility of interactions; however, because of the increased value for hepatic extraction (50 µM) ...
Drugs metabolized by CYP2C9: possible increased plasma concentrations.Specific DrugsDrug Interaction Comments Warfarin Potential for increased plasma warfarin concentrations with intravaginal miconazole Potential for interaction with miconazole applied topically to skin is unknown Do not use intravaginal ...
P4-406: Tarenflurbil (MPC-7869), a selective Aβ42-lowering agent, has no significant effect on drugs metabolized by CYP2C9Background: Alzheimer's disease is the most common type of dementia among the elderly. Its histopathologic features include phosphorylated Tau neurofibrillary tangles and ...
Rosuvastatin is metabolized to a limited extent by CYP2C9 to form an N-desmethyl metabolite and the other metabolite is the rosuvastatin lactone. The acid moeity (highlighted part) is likely to ... xavier_fakerat 5,164 answered Nov 25, 2017 at 20:54 Only top scored, non community-wiki...
21 For intermediate metabolizers with an activity score of 1, meloxicam can be initiated with 50% of the lowest recommended dose with close monitoring, or an alternative NSAID that is not metabolized by CYP2C9 should be used.21 For piroxicam, which has a half-life even longer than ...
Therefore, co-administration of VPA with drugs that are metabolized by CYP2C9 may result in significant drug interactions. CYP2C9 controls the metabolism of 35% to 45% of commonly used drugs including amitriptyline, fluoxetine, doxepin, clomipramine, sertraline, and methadone [82]. Therefore, ...
Concurrent administration of Linezolid does not substantially alter the pharmacokinetic characteristics of (S)-warfarin, which is extensively metabolized by CYP2C9. Drugs such as warfarin and phenytoin, which are CYP2C9 substrates, may be given with Linezolid without changes in dosage regimen....
Midazolam : midazolam is extensively metabolized by CYP3A4. Coadministration with Agenerase with or without ritonavir may cause a large increase in the concentration of this benzodiazepine. No drug interaction study has been performed for the co-administration of Agenerase with benzodiazepines. Bas...
After either oral or intravenous administration of 14 C irbesartan, about 20 % of the radioactivity is recovered in the urine, and the remainder in the faeces. Less than 2 % of the dose is excreted in the urine as unchanged irbesartan. Hydrochlorothiazide is not metabolized but is ...
Metabolized principally by CYP2C9. Does not substantially induce or inhibit CYP1A1, 1A2, 2A6, 2B6, 2D6, 2E1, or 3A4.Drugs Affecting Hepatic Microsomal EnzymesPotential pharmacokinetic interaction (decreased irbesartan metabolism) with CYP2C9 inhibitors....