Upton 1997 Microscopic evaluation revealed that hypericin accumulates in secretory cell globules within these plant structures.Liu 1999 Numerous reports concerning high-performance liquid chromatography analysis of hypericin in St. John's wort exist.Balogh 1999, Chi 1999, Fourneron 1999, Michelitsch 2000...
crystalline substance in water comprises two main contributions: (a) crystal lattice effect (XTL), related to the energy needed to break down the lattice to form a hypothetical ‘supercooled liquid’ (SCL), and (b) solvation effect, related to the energy released as the SCL dissolves in ...
and other tiny bioactive compounds, could be extracted and recovered using systems comprising two liquid phases at certain critical concentrations1,2. To retain the structure and function of such compounds, biphasic systems with two water-rich phases are preferable to those with one aqueous and one ...
Hypersensitivity to valproic acid, divalproex, derivatives, or any component of the formulation; hepatic disease or significant impairment; urea cycle disorders; prevention of migraine in pregnant women and women of childbearing potential who are not using effective contraception; known mitochondrial ...
with all frequently used liquid chromatographic detectors44. From the previous, it was predicted that the overall pH range of methanol with the selected aqueous mobile phases was 4.8 ± 0.5 (in the case of 0.1% (v/v) acetic acid) or 7.5 ± 0.5 (in the case of water and ammonium acetate...
Targeted delivery of hydrophobic chemotherapeutic drugs to tumor cells remains a fundamental problem in cancer therapy. Effective encapsulation of hydrophobic drugs in nano-vehicles can improve their pharmacokinetics, bioavailability and prevent off-targ
Mathematically, the VTO for a particular process is calculated by the total volume of all reactors (m3) that are occupied times the hours per batch divided by the output for that batch of API or intermediate (measured in kg). The process chemistry group at Boehringer-Ingelheim, for example,...
However, those procedures involve the use of very complex and expensive instrumentation and, as alternative, psychoactive substances analysis in biological matrices can be carried out by solid phase extraction (SPE) or liquid phase microextraction (LPME) followed by LC-MS [21,22] and GC-MS with ...
Measure the oral liquid with the marked dosing syringe that comes with the package. Your dose needs to be measured and given accurately to avoid an overdose. DosingThe dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. ...
Recommended therapeutic range of 3–8 ng/mL is based on a liquid chromatography-tandem mass spectrometry (LC/MS/MS) assay method. May measure concentrations by chromatographic or immunoassay methodologies; however, the measured concentrations depend on the type of assay used, and individual patient ...