A better indication of infant exposure to a drug is the steady-state plasma drug concentration in a breast-feeding infant, the major determinants of which are the dose rate (via milk) and the oral availability and clearance in the infant. Although in neonates the rate of absorption may be d...
Fenugreek has been used to stimulate milk production in breast-feeding mothers, but data are insufficient to determine its efficacy and safety, and the extent of transmission of fenugreek-derived constituents into breast milk is unknown. Interactions...
SSRIs cause less impairment on tests of cognition and psychomotor functioning, including tests that reflect performance in real life situations. This suggests that they could be less liable to cause, or contribute to, accidents in the home, in the ...
39 The AED level in the child from breastfeeding is dependent on multiple factors, including the amount of AED excreted into breast milk, the amount of breast milk consumed by the infant, the amount of AED absorbed, and the clearance of the AED by the infant.40 Therefore, the amount of ...
Trials are lacking for the specific use of flaxseed in breast cancer,(27) and the relevance of omega-3 fatty acids or ALA in risk of breast cancer is debated.(31) In a small study in newly diagnosed postmenopausal breast cancer patients, dietary flaxseed showed positive effects on tumor mark...
(REF. 87), lowmolecular mass MAG antagonists with nanomolar affinity and excellent stability in the spinal cord fluid have been identified (S. Mesch, D. Moser, A. vedani, B. Cutting, M. Wittwer, H. Gäthje, S. Shelke, D. Strasser, O. Schwardt, S. Kelm and B. Ernst, ...
The drug crosses the placenta and is found in amniotic fluid and fetal blood; it is also present in breast milk. Cyclosporin is metabolised by cytochrome P-450IIIA enzymes, predominantly in the liver, but some presystemic metabolism by P-450IIIA enzymes in the gastrointestinal mucosa may also ...
Cefotaxime efficiently crosses the placenta, but penetration into breast milk is minimal. Cefotaxime undergoes hepatic metabolism to form desacetylcefotaxime. The latter undergoes further metabolism to inactive opened β-lactam ring lactones. About 80% of a radiolabelled dose of cefotaxime is excreted in...
Distributed into human milk; not known whether the drug affects the breast-fed infant or affects milk production.Consider benefits of breast-feeding and the importance of linezolid to the woman along with potential adverse effects on the breast-fed child from the drug or from the underlying ...
Distributed into epithelial lining fluid of pulmonary tissue in concentrations higher than plasma concentrations.Distributed into milk in rats; not known whether distributed into human milk.Plasma Protein Binding70–90% bound to plasma proteins.