Behavioral sensitization in mammals, including humans, is sensitive to factors such as administration route, testing environment, and pharmacokinetic confounds, unrelated to the drugs themselves that are difficult to eliminate. Simpler animals less susceptible to these confounding influences may be advantageo...
Deworming drugs for treating soil-transmitted intestinal worms in children: Effects on growth and school performance. Cochrane Database Syst Rev. 2007, Issue 4. Art. No.: CD000371. DOI:10.1002/14651858.CD000371.pub3.Taylor-Robinson D, Jones A, Garner P: Deworming drugs for treating soil...
It is FDA approved for use in humans to treat a variety of parasitic infections including parasitic worms, hookworm and whipworm. Ivermectin may also be used as an effective treatment for a wide range of other conditions and as a treatment of onchocerciasis, intestinal strongyloidiasis and ...
volvulus worms, but decreases microfilarial load in skin for approximately 6–12 months following a single dose.Treatment of filariasis caused by Mansonella streptocerca† [off-label]. Diethylcarbamazine (available in US from CDC) and ivermectin are drugs of choice. Diethylcarbamazine is ...
We demonstrated that dietary supplementation of the worms with an extract from the cultivated red seaweed Chondrus crispus decreased the accumulation of α-synulein and protected the worms from the neuronal toxin-, 6-OHDA, induced dopaminergic neurodegeneration. These effects were associated with a ...
Worms were maintained individually in the wells of a 24-well plate in 2 ml of Minimum Essential Medium containing 10% heat-inactivated FCS, 200 U/ml penicillin, 200 μg/ml streptomycin and 50 μg/ml amphotericin B (Sigma), at 36.5°C with 5% CO2 for 24 h until the addition of drugs...
“That’s been demonstrated to work on everything from worms to flies to mice to monkeys. If you can find a way to get people to chronically reduce their caloric intake, it sort of makes sense that it might have an effect on aging. It’s pr...
From worms to drug candidate: the story of odilorhabdins, a new class of antimicrobial agents. Front Microbiol. 2019;10:2893. doi:10.3389/fmicb.2019.02893 106. Pantel L, Florin T, Dobosz-Bartoszek M, et al. Odilorhabdins, antibacterial agents that cause miscoding by binding at a new ...
The roundworms used for the study are similar to humans in their molecular makeup, raising the possibility that the drugs could also extend the life span of humans。 第41题:“By finding a class of drugs that delays aging we have found a relationship between the function of the nervous ...
Researchers from the Walter and Eliza Hall Institute have for the first time identified a 'programmed cell death' pathway in parasitic worms that could one day lead to new treatments for one of the world's most serious and prevalent diseases.