Rheumatoid arthritisAntidiabetic drugsMendelian randomizationDrug repurposingDespite increasing therapeutic options to treat rheumatoid arthritis (RA), many patients fail to reach treatment targets. The use of antidiabetic drugs like thiazolidinediones has been associated with lower RA risk. We aimed to ...
Abstract The introduction of medications that target specific proinflammatory cytokines has revolutionized the management of patients with rheumatoid arthritis. The agents that antagonize the effects of tumour necrosis factor (TNF)-α — infliximab, etanercept and adalimumab — have consistently shown very g...
Rheumatoid Arthritis: National Clinical Guideline for Management and Treatment in Adults There are over 400,000 people with rheumatoid arthritis (RA) in the UK. Although this makes it a common disorder, there are numerous other conditions ahead of it in terms of numbers, and indeed as causes ...
Time for Development. The timeline of the drug development process for repurposed drugs can be estimated using ClinicalTrials.gov and [10,15,16,17,18]. We estimate an average duration of 1 year for phase 1, 2 years for phase 2, 2 years for phase 3, and 1 year for FDA submission-to...
Dr. Sara Imarisio, Head of Research at Alzheimer's Research UK, said: "There is increasing evidence of a key role for inflammation in diseases like Alzheimer's and this has led researchers to investigate whether drugs used to treat inflammatory diseases, likerheumatoid arthritis, could also bene...
An autoimmune disease such as lupus erythematosus or rheumatoid arthritis[21] may attack healthy collagen fibers. Many bacteria and viruses secrete virulence factors, such as the enzyme collagenase, which destroys collagen or interferes with its production. Molecular structure A single collagen molecule,...
Rheumatoid arthritis (RA) is a chronic autoimmune disease that causes inflammation of joints (leading to their destruction), tissues around joints and other organ systems. The pathogenesis of RA is the subject of ongoing research, but the roles of tumour necrosis factor α (TNF-α), interleukin...
RJ Griffiths - 《Mechanisms & Models in Rheumatoid Arthritis》 被引量: 5发表: 1995年 [New drugs for horses and production animals in 2019] In 2019, one novel pharmaceutical agent for horses or food-producing animals was released on the German market: An injection suspension for horses contain...
Rheumatoid arthritis (RA) is a chronic, disabling disease of the synovial joints, thought to be autoimmune in origin. The emergence of biologic therapies has proven to be highly successful in effectively treating RA in the majority of cases. However, the cost of these agents is high and some...
Groups of 15 patients with active rheumatoid arthritis were treated for 24 weeks with zinc sulphate, trien, captopril, clozic in two doses or a combination of d-penicillamine and hydroxychloroquine. Serum histidine levels were monitored along with measures of disease activity including C-reactive pro...