Rheumatoid arthritis (RA) is a chronic, progressive autoimmune disease that causes inflammation and destruction of the joints. 1-3 It can also affect the eyes, the heart and the lungs and is associated with significant disability and increased mortality. RA is estimated to affect just under 1% ...
Health plan offeringsfor RA is the upcoming market trend. In the United States, the expense of managing Rheumatoid Arthritis (RA) continues to escalate, despite regulatory efforts to contain costs. The cost of popular RA treatments, such as HUMIRA and Enbrel, has risen significantly. For instance...
Abstract The introduction of medications that target specific proinflammatory cytokines has revolutionized the management of patients with rheumatoid arthritis. The agents that antagonize the effects of tumour necrosis factor (TNF)-α — infliximab, etanercept and adalimumab — have consistently shown very g...
Therapeutic equivalence of biosimilar and reference biologic drugs in rheumatoid arthritis: a systematic review and meta-analysis. JAMA Netw Open. 2023;6(5):e2315872. doi:10.1001/jamanetworkopen.2023.15872 PubMedGoogle ScholarCrossref 13. Yang J, Yu S, Yang Z, et al. ...
The incidence of schizophrenia has been shown to be high in patients with immune-mediated inflammatory diseases such as inflammatory bowel disease, rheumatoid arthritis and multiple sclerosis40. Amiloride With our focus on candidate drugs for repurposing (i.e. those that exhibited a negative ...
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(OA), rheumatoid arthritis (RA), juvenile rheumatoid arthritis (in patients aged ≥2 years) and ankylosing spondylitis (AS), the management of acute pain in adults, the treatment of primary dysmenorrhoea and the reduction in the number of adenomatous colorectal polyps in familial adenomatous ...
Drug repurposing is the use of a given therapeutic agent for indications other than that for which it was originally designed or intended. The concept is appealing because of potentially lower development costs and shorter timelines than are needed to pr
There is limited evidence supporting a role for vitamin E supplementation in treating or preventing cancer, CNS diseases (eg, Parkinson disease, epilepsy, Down syndrome), liver diseases, macular degeneration and cataracts, menopause, osteoporosis, rheumatoid arthritis, and osteoarthritis; data are often...
(PMTAG_PSC = 2.19 × 10−14). rs3757387 has been previously reported for significant associations with systematic lupus erythematosus among diverse populations44and in a single population19,45, rheumatoid arthritis in multiple populations46,47, and Sjögren’s syndrome48. AnNKX2-3...