New Targeted Drugs for Acute Myeloid Leukemia and Antifungals: Pharmacokinetic Challenges and Opportunitiesdoi:10.1159/000530447ACUTE myeloid leukemiaANTIFUNGAL agentsPHARMACOKINETICSDRUG monitoringLEUCOCYTESBackground: Acute myeloid leukemia (AML) is a life-threatening disease whose treatment is made ...
Sweet's syndrome is an acute febrile neutrophilic dermatosis which can be associated with anticancer drugs. Herein we report two cases of Sweet's syndrome in association with recently approved drugs for acute myeloid leukemia: FLT3 inhibitor Midostaurin and IDH 2 inhibitor Enasidenib. In both cases...
Acute promyelocytic leukemia is a common malignant disease of hematopoietic tissue. T (15, 17) chromosome rearrangements lead to this malignant tumor. APL is characterized by representative promyelocytic leukemia protein/retinoic acid receptor a gene fusion and high invasiveness and infiltration in clinical...
Drugs introduced over the past 25 years have benefitted many patients with acute myeloid leukemia (AML) and provided cure for some. Still, AML remains difficult to treat, and most patients will eventually die from their disease. Therefore, novel drugs and drug combinations are under intense inves...
Effect and prognostic analysis of treatment for acute myeloid leukemia using Chinese drugs combined with chemotherapy. Chin J Integr Med 2009;15:193-197.Xiao-mei Hu,Feng Liu,Chun-mei Zheng,Liu Li,Chi Liu,Shan-shan Zhang,Hai-yan Xiao,Xiao-hong Yang,Hong-zhi Wang,Yong-gang Xu,Nai-ping Hu...
In addition, AML cells from Blood Cancer Journal H3K9 methyltransferases in acute myeloid leukemia Y-S Lai et al 4 Figure 2. Induction of CD11b expression and differentiation by chaetocin. (a) Cells were treated with UNC0638 (20 μM) or chaetocin (20 nM) for 48 h. Expression of CD11b...
In June, HYML-122, a drug targeting acute myeloid leukemia, was approved by the SDA for a clinical trial. It was developed by a research team from Hefei Institute of Physical Science. If the trial is successful, the drug will be put into clinical use in five years. ...
Acute myeloid leukemia (AML) is the second most-common form of leukemia in children. Although, the 5-year survival rate for children with AML is estimated at 64%, nearly half of the patients have refractory disease. Novel targeted therap... A Gopalakrishnapillai,EA Kolb,SP Barwe - 《Cancer...
Drugs introduced over the past 25 years have benefitted many patients with acute myeloid leukemia (AML) and provided cure for some. Still, AML remains difficult to treat, and most patients will eventually die from their disease. Therefore, novel drugs and drug combinations are under intense inves...
Intriguingly, among these tumor samples with an ESC-like signature, we found enrichment for cancer types of the female reproductive tissue with the highest proportion in breast cancer, as well as a relatively high proportion and high enrichment for acute myeloid leukemia (Supplementary Table 4). ...