Therefore, in each D-period repeat of the microfibril, there is a part containing five molecules in cross-section, called the “overlap”, and a part containing only four molecules, called the “gap”.[24] The
Besides parent drugs containing aliphatic alcohols, those with phenolic moieties are also applicable to design as phosphomonoester prodrugs (Figure 5) [36]. For example, fosfestrol sodium* (15) is an estrogen receptor (ER) agonist in prostatic cancer therapy and this drug is derived from the ...
Based on the synthetic optimization, introducing a boron ester functional group to the two furanic indicators endows the stimulus-responsive properties synergistically. The ring-opening reaction of the indicators in the presence of amine-containing illicit drugs generated well-known donor–acceptor ...
The potencies of steroidal antedrugs containing either a 21-chlorine or a 21-hydroxyl group, depend little on the 17c~-OH functional group. Another modification at 21-OH was performed by employing various anhydrides to esterify 21-OH of FP16CM, Scheme 10 (Ko et al., 2001). Dose-...
The second approach involves mRNA vaccines, which activate the body’s immune response to combat infectious diseases and tumors by directly translating mRNA-containing antigen proteins. Compared with traditional inactivated vaccines, mRNA vaccines have advantages such as cell-free production, high production...
step 3—To the concentrated oil from step 2 containing 26 was added TEA (2.34 kg) and TEA-trihydrofluoride (1.63 kg). The mixture was heated to 85° C. for 2 h. The batch was sampled to monitor the progress of the reaction by GC. After the reaction was complete conc. HCl (2.35 ...
The second approach involves mRNA vaccines, which activate the body’s immune response to combat infectious diseases and tumors by directly translating mRNA-containing antigen proteins. Compared with traditional inactivated vaccines, mRNA vaccines have advantages such as cell-free production, high production...
NMP was shown to successfully reduce the gelation of N-stearoyl-L-alanine methyl ester (SAM) containing gel allowing subcutaneous injection in rats [89]. For example, Vintiloiu et al. prepared rivastigmine oleogel using N-stearoyl-L-alanine methyl ester (SAM) gelator in safflower oil for ...
berghei of carboxylic ester and carbonate compounds of dihydroartemisinin. Additionally, Yu and co-workers synthesized C10-substituted benzoates of dihydroartemisinin. The biological results indicated that the halogen- and nitro-containing molecules were similar to artemisinin in activity14, 15, except ...
Formation of the THP ring was accomplished by reaction with KHMDS which allowed for displacement of the mesylate with the secondary alcohol and provided the THP containing product in 72% yield for the three steps. The pivalate ester group was removed with DIBAL-H to give the western fragment 22...