Drugs have shown significant contribution in inducing anemia via hemolysis and bone marrow suppression inan infective endocarditis patient.SinghAjitN. ShettyPrasadMohan Kumar SinghBrijDevasiaTomCardiovascular & Haematological Disorders - Drug Targets(Formerly Current Drug Targets - Cardiovascular & Hematological...
guideline also states that mTOR inhibitors do not improve patient outcomes when administered either as replacement agents for calcineurin inhibitors or antiproliferative agents, or as add-on therapy, and possess significant acute and chronic adverse effects (e.g., dyslipidemia, bone marrow suppression)...
The recommended dosage of DIFLUCAN for suppression of relapse of cryptococcal meningitis in patients with AIDS is 200 mg once daily. Prophylaxis in patients undergoing bone marrow transplantation: The recommended DIFLUCAN daily dosage for the prevention of candidiasis in patients undergoing bone marrow ...
1.3. pharmacological action: This product has immunosuppressive effect, mainly acts on T lymphocytes, inhibits the secretion of cytokines such as interleukin, and reduces the immune function of the body, but the bone marrow suppression is not strong. 1.4, adverse reactions: common kidney toxicity, ...
Reversal of azidothymidine-induced bone marrow suppression by 2′,3′-dideoxythymidine as studied by hemopoietic clonal culture. AIDS Res. hum. Retrovir. 6, 929–932 (1990). Article CAS PubMed Google Scholar Falcone, A., Darnowski, J.W., Ruprecht, R.M., Chu, S.H., Brunetti, I. &...
Nanoparticles releasing an oxaliplatin prodrug and a cationic DNA intercalator within temozolomide-resistant gliomas in mice after convection-enhanced delivery inhibit the growth of the tumours without causing any detectable toxicity. Yongheng Wang Yuhang Jiang W. Mark Saltzman Article27 May 2021 Nature ...
[86]. It also has immunosuppressive activity because it interferes with lymphoid cell proliferation [76]. Likely side effects of brequinar include bone marrow suppression, leukocyte reduction, thrombocytopenia, and gastrointestinal disorders due to the antimetabolite activity of the drug [86]. Bre...
against a broad range of helminths, benzimidazoles are also active against many protozoans, fungi, and viruses, and their use for inhibiting mitosis and cell cycle progression in cancer cells is under study.[2]Possible side effects of their use include liver damage and bone marrow suppression. ...
In a study of rats, administering boron adjunctively with cyclophosphamide significantly reduced bone marrow suppression, as evidenced by significant improvements in leukocytes and platelets (P<0.001 for each). Although erythrocytes were improved with the addition of boron compared with cyclophosphamide alon...
Unexpectedly severe (sometimes fatal) bone marrow suppression, aplastic anemia, and gastrointestinal toxicity have been reported with concomitant administration of methotrexate (usually in high dosage) along with some nonsteroidal anti-inflammatory drugs (NSAIDs). Hepatotoxicity, fibrosis, and cirrhosis ...