Next-in-classWhile new drug approvals by the U.S. Food and Drug Administration (FDA) had remained stable or even increased in the first 2years of the COVID-19 pandemic, the 37 newly approved drugs in 2022 are considerably less than the 53 and 50 new drugs approved in 2020 and 2021,...
Our analyses follow the same protocol as those for newly approved drugs in 2020–2022 (Kayki-Mutlu and Michel2021; Kayki-Mutlu et al.2022,2023) with one exception. Unlike in previous years, we have included cellular and gene therapies approved by the FDA (U.S. Food and Drug Administration...
As of November 2022, the FDA has approved 14 different ADCs, including Lumoxiti (moxetumomab pasudotox-tdfk), which we consider an immunotoxin. The listing of Antibody-drug conjugates(ADCs) Approved by FDA: ADC Drug Trade name Maker Disease Indication Payload/Payload Class Payload Action Target...
摘要: In 2022, 23 new small molecule chemical entities were approved as drugs by the United States FDA, European Union EMA, Japan PMDA, and China NMPA. This review describes the synthetic approach demons...收藏 引用 批量引用 报错 分享 ...
Natural products (NPs) have consistently played a pivotal role in pharmaceutical research, exerting profound impacts on the treatment of human diseases. A significant proportion of approved molecular entity drugs are either directly derived from NPs or indirectly through modifications of NPs. This review...
The U. S. Food and Drug Administration( FDA) approved a 10-year high of 45 new molecular entities( NMEs) in 2015,including 33 new drug applications( NDAs) and 12 new biological applications( BLAs). Among these approvals,16 first-in-class drugs confirmed the creativity and 15 related thera...
Drugs approved by National Medical Products Administration (NMPA) with new generic names between January 1, 2017, to June 30, 2022. Drugs with major indication changes approved by NMPA between January 1, 2017, to June 30, 2022. Drugs in the...
Placement of selected new FDA-approved drugs in Medicare Part D formularies, 2009-2013.In the present work, we synthesized the carbon quantum dots (CQDs) by one step hydrothermal method using the dried beet powder as the carbon ... BC Stuart,SE Tom,M Choi - 《Journal of Fluorescence》 被...
10 compounds showedin vivoefficacy to some extent. When thein vivoexperiment was repeated for these 10 compounds, the following three FDA-approved anti-cancer drugs consistently showed statistically significantin vivoefficacy: streptozotocin (STZ), floxuridine (FU) and doxorubicin (Fig.1b and c). Th...
Discovery of SARS-CoV-2 antiviral synergy between remdesivir and approved drugs in human lung cells ArticleOpen access02 November 2022 A viral RNA-dependent RNA polymerase inhibitor VV116 broadly inhibits human coronaviruses and has synergistic potency with 3CLpro inhibitor nirmatrelvir ...