The severe side effects of some drugs can threaten the lives of patients and financially jeopardize pharmaceutical companies. Computational methods utilizing chemical, biological, and phenotypic features have been used to address this problem by predicti
Coca plantations are the largest illegal agribusiness in the world, and Colombia is the world's leading coca producer. Since 1994, the Colombian state, with the aid of the US, has waged a war on drugs based on air fumigation of coca plantations. This article evaluates the social and environ...
Different drugs ingested in the body have their own toxic and side effects and produce withdrawal symptoms, which can cause direct and serious damage to health, and even overdose and even death. //2. 祸及家庭 一个人一旦吸毒成瘾,就意...
It was found to have potential against colon, lung, ovarian and breast cancer but, due to its poor solubility and low bioavailability, its pharmacological effects are limited. Kakran et al. used bottom-up and top-down approaches as side reduction techniques to prepare nanoparticles [15]. High...
Drugs.com is the most popular, comprehensive and up-to-date source of drug information online. Providing free, peer-reviewed, accurate and independent data on more than 24,000 prescription drugs, over-the-counter medicines & natural products. FDA Approves Opdivo Qvantig (nivolumab and ...
A mathematical model was used to analyze the dynamics of latently and productively infected brain macrophages during viral infection and this mathematical model enabled prediction of the effects of LRAs applied to the "Shock and Kill" strategy in the brain. The model was calibrated using reported ...
The effects of metronidazole and furazolidone on Giardia lamblia trophozoites were analyzed by video-light and transmission electron microscopy. In addition, growth curves were drawn based on four concentrations of the drugs. The IC50 was 4.6 microM for metronidazole and 2.9 microM for furazolidone....
Neonatal exposure to oestradiol increases dopaminergic transmission in nucleus accumbens and morphine‐induced conditioned place preference in adult female... Steroid sex hormones produce physiological effects in reproductive tissues and also in nonreproductive tissues, such as the brain, particularly in corti...
We evaluated two marketed and effective AEDs—one narrow-spectrum [carbamazepine (CBZ)], and one broad-spectrum [levetiracetam (LEV)]—using a novel double-blinded, cross-over outpatient version of the trial to detect acute drug effects of the two marketed AEDs on photosensitivity. We tested 6...
. It may be more difficult to fly east, when time is lost, rather than to fly west, when you gain it back. High doses, such as 20 mg pills are available for purchase on the Internet, but such high doses are not normally recommended or needed, and may greatly increase side effects...