网络类药性 网络释义 1. 类药性 类药性(drug-likeness)在药物开发早期阶段具有重要的指导意义。通过对已批准上市药物的分析发现,大部分药物的一些常 … www.neotrident.com|基于3个网页
1) drug-likeness 类药性1. The studies of compounds becoming safe and orally bioavailable medicines have led to the concept of drug-likeness . 类药性是人们在对安全、可以口服的药物性质的研究中产生的概念。2. The purpose of drug screening is to search for ligands which can be combined with ...
Drug-likeness, a qualitative property of chemicals assigned by experts committee vote, is widely integrated into the early stages of lead and drug discovery. Its conceptual evolution paralleled work related to Pfizer's rule of five and lead-likeness, and is placed within this framework. The ...
Druglikeness is a qualitative concept used in drug design for how "druglike" a substance is with respect to factors like bioavailability. It is estimated from the molecular structure before the substance is even synthesized and tested. A druglike molecule has properties like this: Optimal ...
s and Drug-Likeness Chapter 12 – Lead-Likeness and Drug-LikenessChapter 12 – Lead-Likeness and Drug-LikenessSeveral major changes in drug discovery paradigms have occurred, driven both by the pressure to increase the productivity of pharmaceutical research and by expanding knowledge of ...
First, the impact of molecular physicochemical properties and structural fingerprints on the prediction accuracy of drug-likeness was examined. We found that, compared with simple molecular properties, structural fingerprints were more essential for the accurate prediction of drug-likeness. Then, a ...
类药性,drug-likeness sexual hormones性激素类药 3)1 1,2,4 triazole chiral compound三唑类手性农药 4)anthracycline basic drugs蒽环类碱性药物 1.Hydrophilic interaction chromatography(HILIC) has been applied for the separation of anthracycline basic drugs using high purity silica column with an aqueous-...
Lipinski's Rule of Fiveis a refinement of drug-likeness and is used to predict whether a chemical compound will have pharmacological or biological activity as an orally active drug in humans. This rule was formulated by Christopher A. Lipinski in 1997, based on the observation that most medicat...
Our previous work was focused on the fundamental physical and chemical concepts behind “drug-likeness” and “natural product (NP)-likeness”. Herein, we discuss further details on the concepts of “drug-likeness”, “lead-likeness” and “NPlikeness”. The discussion will first focus on NPs ...
Drug-likeness analysis of traditional Chinese medicines: 2. Characterization of scaffold architectures for drug-like compounds, non-drug-like compounds, an... BackgroundIn order to better understand the structural features of natural compounds from traditional Chinese medicines, the scaffold architectures ...