Association of apo E polymorphism with nutritional and drug-induced changes in lipoproteinsThis literature review presents data on pharmacological action of pravastatin, its lipid lowering activity, and influence on main mechanisms of atherogenesis. Beneficial pleiotropic (nonlipid) effects of pravastatin: ...
10 mg/kg of 17b-estradiol had no effect on LI, whereas female and male rats treated with 50 and 150 mg/kg of 17b-estradiol persisted in showing LI. ANOVAs yielded a significant main effect of pre-exposure (females: F(1, 41) ¼ 8.1, po0.01; males: F(1, 54) ¼ 18.7, po...
Less than a decade ago, it was shown that bromodomains, acetyl lysine ‘reader’ modules found in proteins with varied functions, were highly tractable small-molecule targets. This is an unusual property for protein–protein or protein–peptide interacti
aBy analogy to drug dependence, it has been speculated that the underlying pathology in pathological gambling is a reduction in the sensitivity of the reward system. 由比喻到毒瘾,它推测部下的病理学在病理性赌博是对奖励系统的敏感性的减少。 [translate] ...
Take it orally with or without food (it's recommended that prednisone be taken with food). Commonly used dosage is various from 5 to 60 mg per day and often is adjusted based on the response of the condition being treated. Corticosteroids should be used for several days for best result. ...
Moreover, it was demonstrated that apoptosis of sinusoidal cells, a major problem in liver transplantation caused by cold ischemia–warm reperfusion liver injury, could be effectively reduced by IDN-6556 in an animal model.63In contrast to prior experiments with the caspase inhibitor IDN-1965, whic...
Whether niacin has a beneficial role in lowering cardiovascular risk on the background of well-controlled LDLc has not been established. In fact, it remains unclear whether niacin, either in the setting of well-controlled LDLc or in combination with other lipid-lowering agents, confers any ...
H. Femtosecond Dynamics of a Drug-Protein Complex: Daunomycin with Apo Riboflavin-Binding Protein. Proc. Natl. Acad. Sci. U. S. A. 2001, 98, 11873-11878.Zhong D,,Pal S K,,Wan C,,Zawail A H.Femtosecond dynamics of drug-protein complex: daunomycin with apo riboflavin-binding ...
The cellular FLICE- inhibitory protein (c-FLIP), which is vastly homologous to caspase 8 but lacks enzymatic activity, can also associate with the DISC, blocking activation of caspase 8 through competition for binding sites. It has also been stated that c-FLIP may function as an activator of...
with the reduced quantum yield of the Trp63 fluorescence spectrum for the proton-bound state relative to the deprotonated state (Supplementary Fig.1c) and is reminiscent of the orientations of Glu14 and Trp63 in the drug-free X-ray structure (PDB ID:7MH6). Based on these findings, it ...