In the international sphere, ONDCP views interdiction as an important component of national drug policy. It cooperates with other nations in building their law enforcement institutions, attacking drug production facilities, interdicting drug shipments in both source and transit countries, and dismantling ...
Association of apo E polymorphism with nutritional and drug-induced changes in lipoproteinsThis literature review presents data on pharmacological action of pravastatin, its lipid lowering activity, and influence on main mechanisms of atherogenesis. Beneficial pleiotropic (nonlipid) effects of pravastatin: ...
target RNA structures with small molecules are being actively pursued, aided by key advances in the field including the development of computational tools that predict evolutionarily conserved RNA structures, as well as strategies that expand mode of action and facilitate interactions with cellular ...
At the center of the binding pocket of site 2, located in subdomain IIIA,Diflunisal,diazepam, ibuprofen andindoxyl sulphatebind. It has been shown the presence of drug interactions with thehydroxyl group, on the Tyr410 residue, in contrast to Lys414 that shows no interactions. The residues ...
aBy analogy to drug dependence, it has been speculated that the underlying pathology in pathological gambling is a reduction in the sensitivity of the reward system. 由比喻到毒瘾,它推测部下的病理学在病理性赌博是对奖励系统的敏感性的减少。[translate]...
10 mg/kg of 17b-estradiol had no effect on LI, whereas female and male rats treated with 50 and 150 mg/kg of 17b-estradiol persisted in showing LI. ANOVAs yielded a significant main effect of pre-exposure (females: F(1, 41) ¼ 8.1, po0.01; males: F(1, 54) ¼ 18.7, po...
It is robust with respect to pocket boundary and estimation uncertainties, thus efficient using apo pockets that are challenging to estimate. It clearly distinguishes druggable from less druggable pockets using different estimation methods and outperformed recent druggability models for apo pockets. It can...
H. Zewail, "Femtosecond dynam- ics of a drug-protein complex: Daunomycin with Apo riboflavin-binding protein," Proc. Natl. Acad. Sci. U.S.A., vol. 98, no. 21, pp. 11873-11878, Oct. 2001.Zhong, D., Pal, S. K., Wan, C. and Zewail, A. H., "Femtosecond dynamics of a ...
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Less than a decade ago, it was shown that bromodomains, acetyl lysine ‘reader’ modules found in proteins with varied functions, were highly tractable small-molecule targets. This is an unusual property for protein–protein or protein–peptide interacti