Vasoactive Drug Therapy in ShockKathleen M. Burns RN, MNED * **Critical Care Nursing Clinics of North America
Use of drug therapy in the management of symptomatic ureteric stones in hospitalized adults (SUSPEND), a multicentre, placebo-controlled, randomized trial of a calcium-channel blocker (nifedipine) and an α-blocker (tamsulosin): study protocol for a randomized controlled trial...
Agents that target tumour-supportive cellular machineries, such as the proteasome, heat shock protein complexes and proteins involved in chromatin modifications, are emerging as a new wave of anticancer drugs. Here, Dobbelstein and Moll provide their per
Adenosine signalling has long been a target for drug development, with adenosine itself or its derivatives being used clinically since the 1940s. In addition, methylxanthines such as caffeine have profound biological effects as antagonists at adenosine receptors. Moreover, drugs such as dipyridamole ...
This approach allows us to examine the policy’s effects on different subgroups within the population, such as the location of each player (patient, prescriber, and dispenser), and understand the overall impact on opioid prescribing practices in the state. This approach is used in prior research...
the depressor activity of thiocyanates in experienced hands has been dubious. A number of deaths have occurred, even though the blood level has been carefully controlled. Serious toxicside effects, such asexfoliative dermatitis, have occurred. The use of thiocyanates for therapy of hypertension is ...
For drugs used in the urgent treatment of acute symptoms, little or no delay is anticipated (or desired) between the drug-target interaction and the development of a clinical effect. Examples include vascular thrombosis, shock, malignant hypertension, status epilepticus, or arrhythmias. For many ...
Other analysts have used similar methods with notable differences. For instance, Public Citizen summed R&D spending across major pharmaceutical companies over a 7-year period8 and divided by the number of approval in the subsequent 7-year period. However, this approach compares the cost of developin...
However, drugs used to regulate M1/M2 macrophages have not yet been studied in large randomized clinical trials. Objective To compare the topical application of ON101 cream with use of an absorbent dressing (Hydrofiber; ConvaTec Ltd) when treating DFUs....
However, genetic epidemiology has not yet been used to test the causality of low HDL particle number and coronary heart disease. Two short-term clinical trials of the effects of intravenous reconstituted HDLs on coronary lesions in patients with acute coronary syndrome gave encouraging results, but ...