All were homeless and/or users of illegal drugs, and all survived through intimate involvement in the "street economy"—an informal system of exchange that circulates drugs, sex, and money across a range of settings and participants. Based upon an analysis of life history accounts gained ...
Background Injecting drug use is associated with increased morbidity and mortality. This is the first longitudinal study of a community-based population of injecting drug users (IDUs) in the Republic of Ireland.Aim To establish the natural history of IDUs in a deprived Dublin community.Methods Eigh...
Fig. 5: Genome-wide genotype–phenotype associations underlying resistance towards antifungal drugs. a, Drug-susceptibility data were available for a fraction of our strains (Supplementary Table1), which motivated us to perform a convergence-based GWAS study to understand the genomic determinants of th...
are useful to predict genes involved in clinical adaptation where the relevant phenotypes (such as drug susceptibility or cell adhesion within a patient) are not measurable12,29,30,31. However, our understanding of howCandidaspecies adapt in a clinical context is limited due to many reasons. Firs...
The recent US Food and Drug Administration accelerated approval of bedaquiline, the soon expected approval of delamanid by the European Medicines Agency, and the advanced development of drugs such as PA-824 (TB Alliance) beg the question: how should we use these new drugs in the treatment of ...
Two hundred and seventy-four young people from a variety of back grounds throughout Lincolnshire took part in 35 focus groups to discuss the availability of illicit drugs in the area and attitudes towards their use. They reported that many drugs were freely available and accessible throughout the...
receptor antagonists are administered. These adaptive responses are undoubtedly important when drugs are given over a period of time, and they may account partly for the phenomenon of tolerance (an increase in the dose needed to produce a given effect) that occurs in the therapeutic use of some...
throughout the process of narratively synthesising individual data. The themes were discussed among three members of the research team (AM, CJB, FS) and a peer worker with lived experienced of drug use to ensure they were as accurate a reflection of the lived reality of drug use as could ...
(Tang et al.2023). Zilucoplan has been approved for use in adult patients who are positive for anti-AChR antibodies (Shirley2023b) and granted orphan drug status (Menon and Bril2022). The most common AE are bruising and pain at the injection site, headache, diarrhea, and exacerbation of ...
More importantly for the purpose of our discussion, is that condoms require cooperation from the male partner, and some women may not be able to negotiate condom use [77]. Therefore, female-initiated microbicides have been vastly discussed throughout the last decades to understand what options ...