Wang, P., Read, M., Sims, P. F. G. & Hyde, J. E. Sulfadoxine resistance in the human malaria parasite Plasmodium falciparum is determined by mutations in dihydropteroate synthetase and an additional factor associated with folate utilization. Mol. Microbiol. 23, 979–986 (1997). Article...
Mitochondria is another important organelle that generates ROS and ATP for the cell and plays a role in chemoresistance. A recent study has shown that cancer cells use mitochondrial ATP for ABC transporters activity which expels drugs out of cancer cells and is negatively regulated by methylation-c...
doi:10.1016/j.jalz.2013.08.062Modak, SwanandaSims, PaulKhan, FaridJin, Lee-WayMaezawa, IzumiDoig, AndrewElsevier Inc.Alzheimers & Dementia
In this review, we discuss the use of combination drug therapy from a historical perspective, as well as future options for emerging infectious viral diseases. Historical lessons and clinical implications of drug combination therapy in viral infections HIV In the absence of treatment intervention, ...
The evidence for the use of 4 against COVID-19 is very divided. It would be interesting to conduct broader studies to evaluate the effect of the drug on the different degrees of sever- ity of the disease, in addition to verifying whether viral clear- ance benefits from its use and ...
it is preferable that the device resistance of a Test DPI be comparable to that of the Reference DPI. It has also been suggested that the use of a Test DPI with a comparable air flow resistance to the Reference DPI is expected to increase the likelihood of establishing SAC and APSD equival...
Sims, T.M. Underhill, S.J. Dixon P2X(4) purinoceptors mediate an ATP-activated, non-selective cation current in rabbit osteoclasts J. Cell. Sci., 112 (1999), pp. 4425-4435 CrossrefView in ScopusGoogle Scholar [21] A. Hoebertz, A. Townsend-Nicholson, R. Glass, G. Burnstock, T....
allowing researchers to explore differences in parasite phenotypes as diverse as immune evasion in mosquitoes [4] and red cell invasion [5] to the development of drug resistance [6,7]. However, the most widely studiedin vitroparasite strains or clones have been in use for more than two decade...
basic scientific research in chemistry and biology of natural products has finally borne fruit for natural product-derived antibiotics drug discovery. A batch of new antibiotic scaffolds were approved for commercial use, including oxazolidinones (linezolid, 2000), lipopeptides (daptomycin, 2003), and mu...
Parasite density was determined before use by counting the mobile promastigotes on Neubauer chambers after centrifugation at 3000× g. 2.8. Assessment of Cytotoxicity to CML Cell Lines Cell viability was determined by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium (MTT) colorimetric ...