Target trial emulation (TTE) simulates randomized controlled trials using real world data (RWD). Here, authors show the effectiveness of different TTE strategies to identify drug candidates that could be potentially repurposed to Alzheimer’s disease using two large scale RWD warehouses. Chengxi Zang...
The combined company expects to read out approximately 10 clinical trials in the next 18 months. Recursion and Exscientia said most of their 11 combined pipeline programs, if successful, could generate annual peak sales of more than $1 billion. Oncology accounts for five of the 11 progra...
Strategies to overcome trastuzumab resistance in HER2-overexpressing breast cancers: focus on new data from clinical trials. BMC Med. 12, 132 (2014). Article PubMed PubMed Central Google Scholar D’Amato, V. et al. Mechanisms of lapatinib resistance in HER2-driven breast cancer. Cancer Treat...
over 20 nanomedicines have received clinical therapeutic or diagnostic approval from the FDA or the European Medicines Agency (EMA), and an additional 75 clinical trials examining nanoparticles have been
This sets the stage for the future of cell-based therapy and trials in Canada.” The full article, “Bone Marrow Mesenchymal Stromal Cells in Patients with Osteoarthritis Results in Overall Improvement in Pain and Symptoms and Reduces Synovial Inflammation,” can be accessed at https://stemcells...
The development of immuno-based therapy in breast cancer has made significant progress over the past two decades. Though different immunotherapeutic strategies have been explored in breast cancer, the number of immunotherapy-based clinical trials increased after the advent of immune checkpoint inhibitors ...
Intranasal route has emerged as an alternative to this problem and it may be the future of CNS drug delivery if well-established preclinical or clinical trials are succeeded. The intranasal delivery is a part of transmucosal delivery as therapeutic agents need to diffuse across nasal mucosa in ...
Clinical trial simulation has not been used to assist drug development in the NTD domain, although simulation has been used widely to project the impact of population-level interventions on onchocerciasis, LF and other NTDs42, and to inform the design of cluster intervention trials targeting ...
Furthermore, predictions represent an average response across populations of cell-lines/patients, which mimics the way treatment efficacies are measured in clinical trials. Fig. 1: IDACombo allows drug combination efficacy predictions to be made using monotherapy cell line screening data, and these ...
With more research on PDNAs and parse on the assembly mechanisms, we believe that there will be clinical trials and even medical products of PDNAs in the near future. Acknowledgments This work was supported by Liaoning Science & Technology project (2019-ZD-0465, China). Author contributions ...