Drug insight: thalidomide as a treat- ment for multiple myeloma. Nat Clin Pract Oncol 2005;2: 262e270.Kumar S,Anderson KC.Drug insight: thalidomide as a treatment for multiple myeloma. Nat Clin Pract Oncol . 2005Kumar S,Anderson KC.Drug insight:thalidomide as a treatment for multiple ...
Treatment inhibits key process that enables cancer cells to multiply. Researchers in London plan to begin clinical trials on a significant new treatment for multiple myeloma by the end of next year. In laboratory testing, the drug, known as DTP3, killed myeloma cells within human cells and mice...
Multiple myeloma (MM) is an osteolytic malignancy that is incurable due to the emergence of treatment resistant disease. Defining how, when and where myeloma cell intrinsic and extrinsic bone microenvironmental mechanisms cause relapse is challenging with current biological approaches. Here, we report ...
Treatment for multiple myeloma. Combination chemotherapy with different melphalan dose regimens. JAMA. 1969;208:1680–5. CAS PubMed Google Scholar Attal M, Harousseau J-L, Stoppa A-M, Sotto J-J, Fuzibet J-G, Rossi J-F, et al. A prospective, randomized trial of autologous bone marrow...
unknown cytogenetic risk, and there was an imbalance in patients with high cytogenetic risk between the treatment arms at diagnosis (23.9% vs 16.9%). Additionally, many patients have not yet reached both the 24- and 36-month MRD assessments, requiring longer follow-up for sustained negativity ...
These materials could be incorporated with diverse drugs for the treatment of cancers, bacterial infections, inflammation, etc. 3.3.1. Anticancer drug delivery BTZ is a specific protease inhibitor widely used for the treatment of multiple myeloma, but sometimes not successful for the treatment of ...
defects, has been repurposed to treat conditions such as leprosy and multiple myeloma.18In addition, arsenic trioxide (a poison) and all-trans retinoic acid (a metabolite of vitamin A) are examples of other chemical compounds19that were approved by the FDA in 2000 for the treatment of acute...
A combination therapy is a therapeutic intervention in which more than one therapy is administered to the patient. Examples of combination therapy include treatment regimens that involve administering several separate pills, each containing a particular drug, or single pills that contain several drugs. ...
based on its effect on different organ.Thalidomide, an antiemetic drug recalled forteratogenicityand embryoniclimb deformities, was later approved for the treatment of leprosy andmultiple myelomafor its ability to inhibittumor necrosis factor alphaand angiogenesis (Jacobson, 2000)....
A new review published in Blood Cancer Discovery outlines a major multiple myeloma research project that supported a key regulatory decision by a U.S. Food and Drug Administration committee. The decision greenlights a new biomarker endpoint, minimal resi