For example, through inhibiting OCT2, cimetidine decreases the renal excretion of metformin and increases its plasma concentration99. On the other hand, OCT2, by modulating the exposure of drugs to renal proximal tubule cells regulates the nephrotoxicity of anticancer drug cisplatin and its analogs...
One of the most exciting fields in biomedical research over the past few years is stem cell biology, and therapeutic application of stem cells to replace t... SM An,PD Qiang,Ling-song Li - 《中国药理学报》 被引量: 59发表: 0年 Cancer stem cells: the 'Achilles heel' of chemo-resistant...
Is the main sugar urea guanidine (metformin, glimepiride and acarbose) Acarbose should swallow with the first meal. Glimepiride are advised to take in half an hour before breakfast. Metformin is available after meals. 2 antifungal agents, itraconazole, etc. should be taken with food, which can ...
The European Medicines Agency’s Committee for Medicinal Products for Human Use has recommended the approval of AstraZeneca’s Qtrilmet (metformin hydrochloride, saxagliptin, and dapagliflozin) modified-release tablets for treating type-2 diabetes. ...
Analgaesic Hydrochlorothiazide Diuretic and antihypertensive Buproprion (Wellbutrin; GlaxoSmithKline) Antidepressant Amitriptyline Antidepressant Isoniazid Tuberculosis therapy Metformin Antihyperglycaemic of 100 pairs of crb heterozygotes generated enough embryos to screen 1,000 compounds per week at 20 µM ...
In addition, drugs currently used to treat metabolic disorders (for example, metformin) could extend lifespan and have utility in treating other age-related diseases. Abstract There has recently been significant progress in our understanding of the mechanisms that regulate ageing, and it has been ...
For drugs with low permeability, such as metformin and aliskiren, higher doses have been used in their approved drugs to compensate for their relatively low bioavailability. For example, the strengths of metformin can go as high as 1 g in drug products. Improving bioavailability for drugs with...
Is the main sugar urea guanidine(metformin, glimepiride and acarbose) Acarbose should swallow withthe first meal. Glimepiride are advised totake in half an hour before breakfast. Metformin is available aftermeals. 2 antifungal agents,itraconazole, etc. should be taken with food, which can reduce ...
lower illustration depicts how our model discovers a low-dimensional signature vector for the anti-diabetic drug Metformin and a low-dimensional signature vector for the side effect diarrhoea, such that the dot product of these two signatures models the frequency of diarrhoea in patients on Metformin...
Due to this lacuna, ML algorithms such as SVM and RF (random forest) are used to replace the existing methods in due course. The models of DL are very sophisticated forms of multi-level NNs called deep NNs (DNNs). Using large amounts of labeled or unlabeled training datasets, the DNNs ...