Dose increase In patients with sustained low dose titers, a dose increase of the therapeutic protein may be beneficial. This approach has been adopted in haemophilia A in patients with low titer inhibitors (<5 BU) where modest dose increases has shown to be preventive in bleeding episodes. Thou...
Neutropenia, sometimes triggered by certainchemotherapy drugs, is characterized by a decrease in infection-fightingwhite blood cellscalled neutrophils. Tbo-filgrastim stimulates the bone marrow to increase output of neutrophils. The new drug, injected about 24 hours after chemotherapy is administered, is ...
One of the ways to increase the performance of drug delivery and target the direction of NC’s movement is by using a magnetic field with high efficiency. In this study, we have used the Halbach arrangement in the optimized placement position from the previous study8, in which magnetic nanopa...
Limits to a series of molecular properties of drugs (logP, molecular weight, hydrogen bond donors and acceptors), suggested by Lipinski to increase the likelihood of good oral absorption. Mesenteric lymphatic vessels The lymphatic vessels that collect lymph from the intestine. This includes the initia...
The trillions of microbes that make up the gut microbiome are an important contributor to health and disease. With respect to xenobiotics, particularly ora
on (i) surface modification using ultraviolet-ozone plasma treatment to increase the hydrophilicity of the balloon surface35, (ii) use of microneedle drug-eluting balloon in an atherosclerosis rabbit model36, aim to enhance drug delivery from an inflated balloon and to get better retention. The ...
(colistin) bind tophospholipidsin the cell membrane of the bacterium and interfere with its function as a selective barrier; this allows essential macromolecules in the cell to leak out, resulting in the death of the cell. Because other cells, including human cells, have similar or identical ...
"These white blood cells infiltrate many of the tissues and organs of the affected individuals and is a major cause of death in leukemia patients," said senior author Ali Shilatifard, a Northwestern University professor of biochemistry and molecular genetics and pediatrics. "This is a monster can...
Even 0.2 mg/ml of puromycin caused a significant increase in the male to female ratio, from 43.0 ± 1.3% to 62.7 ± 2.15% (N = 3, P ≤ 0.001; two-sample Student’s t test with equal variance; Fig. 3a). Inversely, supplementing the food with geneticin to ...
Due to the increase in antibiotic resistance, bacterial infections pose a serious threat to human health1,2. There is an urgent need for alternative antibacterial strategies to combat drug-resistant bacteria and biofilm-associated infections in diverse scenarios. Some antibacterial materials such as cati...