Drug-induced cognitive impairment (DICI) is a well-established, yet under-recognised, complication of many types of pharmacological treatment. While there
References 203–205 report some striking phenotypic differences between mouse strains based on genetic variation, illustrating why testing compounds in mice with a single genetic background can be misleading. CAS PubMed Google Scholar Gatti, D. M., Weber, S. N., Goodwin, N. C., Lammert, F...
There is a significant amount of method development and validation needed for each specific application; the behavior of a specific analyte, or mixture of drugs is hard to predict without comprehensive testing, research and development. The optimal choice of substrate, laser wavelength, aggregating age...
Protein kinases regulate nearly all aspects of cell life, and alterations in their expression, or mutations in their genes, cause cancer and other diseases. Here, we review the remarkable progress made over the past 20 years in improving the potency and
I get on the phone with the police. While I’m on the phone, my employee gets a call from a customer. It’s a man stating that the thief is at the park near the store. I hear a little girl in the background yelling, “Daddy, the bad man is in the bathroom!” I relay the ...
Lifeng Kang, in Advanced Drug Delivery Reviews, 2018 4.8 Bioprinting for in vitro drug testing The abovementioned have demonstrated the capacity and competency of AM to create physical (non-cellular) models, which are anatomically accurate and functional – for predicting effects of drug action ...
Food and Drug Administration (FDA) and European Medicines Agency (EMA) have mandated the testing of HLA-B*57:01 before initiating or reinitiating abacavir treatment. Notably, evidence shows that while the 100% NPV for non-carriers is based on stringent immunological confirmation of ABC-HSS via ...
City checking: piloting the UK’s first community-based drug safety testing (drug checking) service in 2 city centres. Br J Clin Pharmacol. 2020;86(3):420–8. https://doi.org/10.1111/bcp.14231. Article PubMed PubMed Central Google Scholar Measham FC. Drug safety testing, disposals ...
In vivo testing of various advanced implant features, such as delayed drug release, multiple therapies, and triggered release. 5. Research toward the possible toxicity of TNTs for situations where loose TNTs can detach from the implant surface. 6. Inclusion of biopolymers and other biomimetic appr...
This novel technology offers a powerful human alternative to animal testing for toxic side effects of new medicines.” A mini kidney from the lab doesn’t look like a normal kidney, but the simple cell structures share many of the characteristics of real kidneys, and researchers can use them ...