Universal Access to HIV Treatment versus Universal 'Test and Treat': Transmission, Drug Resistance & Treatment Costs. In South Africa (SA) universal access to treatment for HIV-infected individuals in need has yet to be achieved. Currently ∼1 million receive treatment, ... Wagner,Bradley,G....
Overall, our data seem to suggest a somewhat – yet only partially closer – connection and involvement of female crack users with care services, which may suggest that women in our study’s local contexts find these services more accessible or useful for their needs (even though most services...
Why does a drug with a well-response for one patient, but not for the next, or in some cases, lead to serious adverse drug reactions (ADRs), namely individual variability in drug response (IVDR)? The answers are complicated and multi-faceted. First of all, therapeutic response rates of d...
Differences between two groups were assessed using Student’s t test, and comparisons among multiple groups were performed using one-way ANOVA. P values were presented using the following asterisk rating system: P < 0.05 *, P < 0.01 **, P < 0.001 ***, and P < 0.0001...
However, Mann㎏endall test showed no significant monotonic relationship (Kendall's tau = 0.32; P = 0.45). Conclusions This study provided significant and real﹚orld evidence about the high prevalence rate of DDI in children receiving depression treatment. There is an urgent need to detect, assess...
A descriptive and inferential analysis was carried out using SPSS (version 24) to determine the strength of the relationships (Pearson Chi Square test) between different variables. Results A total of 10 adverse drug reaction reports were collected during the 3 month period from which 8 were ...
Reduced treatment delays for drug-resistant TB/HIV co-infected patients with decentralized care and rapid Xpert MTB/RIF test in Khayelitsha, South Africa Background: More than 14,000 patients are diagnosed with drug-resistant TB (DR-TB) in South Africa annually, with 65% estimated to be HIV-...
Mean (%) scores for the different HCP categories were compared by analysis of variance (ANOVA), followed by pairwise comparisons using the t test. Statistical significance was set at p < 0.05. An overall mean score (%) with a 95% confidence interval (CI) for all participants was ...
Data are analyzed with one-way ANOVA followed by multiple comparisons test. e Intracellular ATP content in 4T1 cells after different treatments (n = 5 independent experiments). MIT vs. MG@PM: P < 0.001; MIT vs. MG: P < 0.001; GA vs. MG@PM: P < 0.001; GA vs. ...
(Supplementary Fig.5). This prompted us to test for metabolic vulnerability in tumors with mTORC1-mediated resistance to other targeted therapies, such as the PI3K inhibitors (PI3Ki) alpelisib and pictilisib15,49. We generated both alpelisib and pictilisib-resistant subclones of T47D breast ...