where n corresponds to the number of dissolution time points considered and Rt and Tt are the percent drug dissolved of the reference and test formulations at time point t. It is a simple and effective tool to assess the similarity of two dissolution profiles: the value of f2 ranges from 0...
The device is a lateral flow chromatographic immunoassay for the qualitative detection of multiple drugs and drug metabolites in urine, providing a preliminary analytical test result. In addition, this product includes a quality control device built into the test itself, and a red line in the ...
Structure based drug discovery is characterized by the use of molecular targets, most especially proteins, which are as a result of experimental work from X-ray crystallography, NMR or homology modeling and are obtained from databases like the Protein Databank, AlphaFold protein structure database, ...
Shorten the Design-Make-Test-Analyze cycle: D360 is the industry leading drug discovery software for small molecule and biologics discovery research.
Article 134 While verifying the specifications of a new drug, the drug testing institute shall, in addition to sample testing, give verification opinions in respect of the specifications and test items, etc., of the drug referring to the study data, the specifications of the same kind of ...
CCDC/Astex Validation set. The new CCDC/Astex test set consists of 305 protein-ligand complexes. All protonation states have been assigned by manual inspection. It is an extended version of the original GOLD validation test set. SeRAPhiC. Data set of 53 high-quality protein-fragment complexes, ...
Finally, we evaluated MvGraphDTA’s performance on the test set of PDBbind_2016. Experimental results (Table 6) showed that MvGraphDTA exhibited improvements of 3.2%, 4.2%, 1.7%, 0.9%, and 3.6% across MAE, RMSE, PCCs, CI, and R2, respectively. Although the approach of selectively ...
The results from three independent experiments were statistically analyzed using a t-test: *p < 0.05, **p < 0.01, ***p < 0.005. The working model, USP24 promotes drug resistance by decreasing genomic stability and increasing the pumping out of drugs, was shown (B). Full size...
In this work, a ligand based virtual screening was made on a two million compound database using ChemAxon's PF and CCG's GpiDAPH3 fingerprints to test 38 molecules for their ability to affect the functional activity of recombinant human CaV3.2 (Table 1). Sixteen out of the 38 mo...
The lattermost of these effects is seldom investigated in the literature, with articles tending to test drug release systems in saline solution, though it provides key insight into the real-world application of these systems. A selection of recent articles detailing sustained or targeted delivery of...